ID CXCR6_MACNE Reviewed; 342 AA.
AC O19024;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=C-X-C chemokine receptor type 6;
DE Short=CXC-R6;
DE Short=CXCR-6;
DE AltName: Full=G-protein coupled receptor bonzo;
DE AltName: CD_antigen=CD186;
GN Name=CXCR6; Synonyms=BONZO;
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9230441; DOI=10.1038/40894;
RA Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.;
RT "Expression cloning of new receptors used by simian and human
RT immunodeficiency viruses.";
RL Nature 388:296-300(1997).
CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor
CC by SIVs and by strains of HIV-2 and m-tropic HIV-1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF007858; AAB64224.1; -; Genomic_DNA.
DR AlphaFoldDB; O19024; -.
DR SMR; O19024; -.
DR STRING; 9545.ENSMNEP00000026508; -.
DR GlyCosmos; O19024; 1 site, No reported glycans.
DR Proteomes; UP000233120; Whole Genome Shotgun Assembly.
DR Proteomes; UP000694946; Genome assembly.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR CDD; cd15173; 7tmA_CXCR6; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002235; Chemokine_CXCR6.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF705; C-X-C CHEMOKINE RECEPTOR TYPE 6; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01105; CXCCHMKINER6.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="C-X-C chemokine receptor type 6"
FT /id="PRO_0000069368"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 342 AA; 39298 MW; 55F9F68CB62D2DF5 CRC64;
MAEHDYHEDY GLNSFNDSSQ EEHQDFLQFR KVFLPCMYLV VFVCGLVGNS LVLVISIFYH
KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWIFGQV MCKTLLGVYT INFYTSMLIL
TCITVDRFIV VVKATKAYNQ QAKRMTWGKV ICLLIWVISL LVSLPQIIYG NVFNLDKLIC
GYHDKEISTV VLATQMTLGF FLPLLAMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF
LLTQTPFNLV KLIRSTHWEY YAMTSFHYTI IVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
//
