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Database: UniProt
Entry: O22243
LinkDB: O22243
Original site: O22243 
ID   C3H31_ARATH             Reviewed;        1015 AA.
AC   O22243; C0SV94;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1999, sequence version 2.
DT   16-OCT-2019, entry version 138.
DE   RecName: Full=DExH-box ATP-dependent RNA helicase DExH8 {ECO:0000305};
DE            EC=3.6.4.13;
DE   AltName: Full=Zinc finger CCCH domain-containing protein 31;
DE            Short=AtC3H31;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=At2g47680; ORFNames=F17A22.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA   Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA   Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA   Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA   Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA   Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N.,
RA   Takiguchi Y., Takagi M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NOMENCLATURE.
RX   PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA   Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT   "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and
RT   rice.";
RL   BMC Genomics 9:44-44(2008).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=24265739; DOI=10.1371/journal.pone.0078982;
RA   Xu R., Zhang S., Huang J., Zheng C.;
RT   "Genome-wide comparative in silico analysis of the RNA helicase gene
RT   family in Zea mays and Glycine max: a comparison with Arabidopsis and
RT   Oryza sativa.";
RL   PLoS ONE 8:E78982-E78982(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the DExH box helicase family.
CC       {ECO:0000305}.
DR   EMBL; AC005309; AAC63624.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10875.1; -; Genomic_DNA.
DR   EMBL; AB493597; BAH30435.1; -; mRNA.
DR   PIR; C84918; C84918.
DR   PIR; T00416; T00416.
DR   RefSeq; NP_182290.1; NM_130336.3.
DR   SMR; O22243; -.
DR   STRING; 3702.AT2G47680.1; -.
DR   PaxDb; O22243; -.
DR   EnsemblPlants; AT2G47680.1; AT2G47680.1; AT2G47680.
DR   GeneID; 819381; -.
DR   Gramene; AT2G47680.1; AT2G47680.1; AT2G47680.
DR   KEGG; ath:AT2G47680; -.
DR   Araport; AT2G47680; -.
DR   TAIR; locus:2043413; AT2G47680.
DR   eggNOG; KOG0920; Eukaryota.
DR   eggNOG; COG1643; LUCA.
DR   HOGENOM; HOG000082976; -.
DR   InParanoid; O22243; -.
DR   OMA; YDDIMGT; -.
DR   OrthoDB; 101959at2759; -.
DR   PhylomeDB; O22243; -.
DR   PRO; PR:O22243; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O22243; baseline and differential.
DR   Genevisible; O22243; AT.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase;
KW   Metal-binding; Nucleotide-binding; Reference proteome; Repeat;
KW   RNA-binding; Zinc; Zinc-finger.
FT   CHAIN         1   1015       DExH-box ATP-dependent RNA helicase
FT                                DExH8.
FT                                /FTId=PRO_0000371989.
FT   DOMAIN       36    197       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      254    419       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      49     56       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   ZN_FING     727    753       C3H1-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00723}.
FT   ZN_FING     754    782       C3H1-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00723}.
FT   MOTIF       144    147       DEVH box. {ECO:0000305}.
FT   COMPBIAS      8     15       Poly-Ser.
SQ   SEQUENCE   1015 AA;  115085 MW;  D1C342B338C561C9 CRC64;
     MAVSSPTSSS SSSESLPLPS SNFASLPIMA MKRRIIDKIL ENRVTLIVGE PGCGKSSQVP
     QFLLEANMAP ILCTQPRRFA VVAVAKMVAK SRNSDLGGEI GYHIGHSKIL TEGSKILFKT
     AGVLLDEMLD KGLNALKYKV IILDEVHERS VESDLVLVCV KQFLMKNNDL RVVLMSATAD
     ITRYRDYFKE LGRGERVEVV AIPSPDQRTI FQRRVLYLEQ VAGLLGVSSD LSAYCPGPSP
     SSADTEIKPE LQNLIHDLIL YIHEKEPDIE KSILVFLPTY YSLEQQYHQL EPFFASFEVH
     ILHRSIDTEQ ALAAMKICRS RRKVILATNI AESSVTIPKV AYVIDSCRSL QVFWDPSRKR
     DAVQLVWVSR SQAEQRRGRT GRTCDGEVYR LVPSAFFNKL EEHEPPSILK LSLRQQVLHI
     CCTESRAIND ANALLAKAMD PPDPDVVDDA LRMLLSIQAL RKSPRGRYEP TFYGRLLASF
     PLSFDASILV VKFGEMGMLR QGILLGVLMD TLPLPIHHPF GDDSLFLEYV DHYFGGSKTI
     SGGRREMVLM ANFCAFQFWQ RVFKDKHRLE NLKQLLSKEK DKDLKLMFPE IEKEWCDFHN
     IAQSSFYHVS ELYEDTLSSF HRFRPQFISS SDSQPTYYNP YEFDHTCYIE CQPSEDKYLH
     SEDVDNNQPP PEVRKCVSVP FVPPNAFQAN AIAENMASII KEIRTQCTPS ESDNGHGALE
     PEDYVEYGEA PVCVYFLNGY CNRGGQCTFT HTLQSTRPAC KFFASSQGCR NGESCLFSHA
     MRRRTTSYLP PPQCLPEEDG SSTSPLLDLF PTSSEGCILV FDDSDMHFTS SIANRYPSWR
     ILSTSSSSET LFCDSSLADT RIFWGLNHPY QTIISKAGRE NPIPWNEVKC VLWFLNPDSY
     ADTPEKQKTI LQNFFEHMAI RLLGDKLYKI RVVLTMNNVR FSLLQVEKLA RESFFFLGES
     FPHDSESFGA FQDTLTIQKP MLVSRPISYV FNLHPPSDIQ FGNYTSLLRK SLHNK
//
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