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Database: UniProt
Entry: O23372
LinkDB: O23372
Original site: O23372 
ID   ATXR3_ARATH             Reviewed;        2335 AA.
AC   O23372; Q0WVL9;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   13-FEB-2019, entry version 119.
DE   RecName: Full=Histone-lysine N-methyltransferase ATXR3 {ECO:0000305};
DE            EC=2.1.1.43 {ECO:0000269|PubMed:20937886};
DE   AltName: Full=Protein SET DOMAIN GROUP 2;
DE   AltName: Full=Trithorax-related protein 3;
DE            Short=TRX-related protein 3;
GN   Name=ATXR3; Synonyms=SDG2, SET2; OrderedLocusNames=At4g15180;
GN   ORFNames=dl3635w, FCAALL.214;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9461215; DOI=10.1038/35140;
RA   Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA   Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L.,
RA   Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P.,
RA   Wedler H., Wedler E., Wambutt R., Weitzenegger T., Pohl T., Terryn N.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A.,
RA   Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S.,
RA   Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B.,
RA   Mueller-Auer S., Silvey M., James R., Monfort A., Pons A.,
RA   Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P.,
RA   Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T.,
RA   Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W.,
RA   Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W.,
RA   Klosterman S., Schueller C., Chalwatzis N.;
RT   "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of
RT   Arabidopsis thaliana.";
RL   Nature 391:485-488(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA   Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA   Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA   Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA   Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA   Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA   Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA   Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA   van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA   Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA   Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA   Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA   De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA   van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA   Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA   Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA   Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA   Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA   Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA   Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA   Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA   Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA   Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA   Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA   Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA   Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA   Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA   Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA   Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA   Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA   Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA   Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA   Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA   Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA   Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA   Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA   Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-517.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
RA   Hayashizaki Y., Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NOMENCLATURE.
RX   PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA   Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA   Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT   "The Arabidopsis thaliana genome contains at least 29 active genes
RT   encoding SET domain proteins that can be assigned to four
RT   evolutionarily conserved classes.";
RL   Nucleic Acids Res. 29:4319-4333(2001).
RN   [6]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21037105; DOI=10.1105/tpc.110.079962;
RA   Berr A., McCallum E.J., Menard R., Meyer D., Fuchs J., Dong A.,
RA   Shen W.H.;
RT   "Arabidopsis SET DOMAIN GROUP2 is required for H3K4 trimethylation and
RT   is crucial for both sporophyte and gametophyte development.";
RL   Plant Cell 22:3232-3248(2010).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=20937886; DOI=10.1073/pnas.1010478107;
RA   Guo L., Yu Y., Law J.A., Zhang X.;
RT   "SET DOMAIN GROUP2 is the major histone H3 lysine 4
RT   trimethyltransferase in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:18557-18562(2010).
CC   -!- FUNCTION: Histone methyltransferase specifically required for
CC       trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial
CC       for both sporophyte and gametophyte development (PubMed:21037105,
CC       PubMed:20937886).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000269|PubMed:20937886};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and
CC       inflorescences. {ECO:0000269|PubMed:20937886}.
CC   -!- DISRUPTION PHENOTYPE: Pleiotropic effects on plant growth and
CC       development, including dwarf size, aberrant root development and
CC       sterile flowers. {ECO:0000269|PubMed:20937886,
CC       ECO:0000269|PubMed:21037105}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. TRX/MLL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB10297.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB78560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; Z97338; CAB10297.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161540; CAB78560.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE83565.1; -; Genomic_DNA.
DR   EMBL; AK226725; BAE98829.1; -; mRNA.
DR   PIR; G71415; G71415.
DR   RefSeq; NP_193253.4; NM_117606.5.
DR   UniGene; At.21894; -.
DR   UniGene; At.263; -.
DR   ProteinModelPortal; O23372; -.
DR   SMR; O23372; -.
DR   STRING; 3702.AT4G15180.1; -.
DR   iPTMnet; O23372; -.
DR   PaxDb; O23372; -.
DR   PRIDE; O23372; -.
DR   EnsemblPlants; AT4G15180.1; AT4G15180.1; AT4G15180.
DR   GeneID; 827183; -.
DR   Gramene; AT4G15180.1; AT4G15180.1; AT4G15180.
DR   KEGG; ath:AT4G15180; -.
DR   Araport; AT4G15180; -.
DR   TAIR; locus:2129755; AT4G15180.
DR   eggNOG; KOG1080; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000034228; -.
DR   InParanoid; O23372; -.
DR   KO; K22748; -.
DR   OMA; KQPQRPW; -.
DR   OrthoDB; 28425at2759; -.
DR   PhylomeDB; O23372; -.
DR   PRO; PR:O23372; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   Genevisible; O23372; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:TAIR.
DR   GO; GO:0048440; P:carpel development; IMP:TAIR.
DR   GO; GO:0009791; P:post-embryonic development; IMP:TAIR.
DR   GO; GO:0048443; P:stamen development; IMP:TAIR.
DR   GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR   InterPro; IPR035445; GYF-like_dom_sf.
DR   InterPro; IPR025640; GYF_2.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF14237; GYF_2; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF55277; SSF55277; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Complete proteome; Methyltransferase; Nucleus;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1   2335       Histone-lysine N-methyltransferase ATXR3.
FT                                /FTId=PRO_0000233360.
FT   DOMAIN     1765   1904       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   COMPBIAS    435    529       Arg-rich.
FT   COMPBIAS   1535   1573       Ser-rich.
SQ   SEQUENCE   2335 AA;  267060 MW;  26BA2C3AF6B346EA CRC64;
     MSDGGVACMP LLNIMEKLPI VEKTTLCGGN ESKTAATTEN GHTSIATKVP ESQPANKPSA
     SSQPVKKKRI VKVIRKVVKR RPKQPQKQAD EQLKDQPPSQ VVQLPAESQL QIKEQDKKSE
     FKGGTSGVKE VENGGDSGFK DEVEEGELGT LKLHEDLENG EISPVKSLQK SEIEKGEIVG
     ESWKKDEPTK GEFSHLKYHK GYVERRDFSA DKNWKGGKEE REFRSWRDPS DEIEKGEFIP
     DRWQKMDTGK DDHSYIRSRR NGVDREKTWK YEYEYERTPP GGRFVNEDIY HQREFRSGLD
     RTTRISSKIV IEENLHKNEY NNSSNFVKEY SSTGNRLKRH GAEPDSIERK HSYADYGDYG
     SSKCRKLSDD CSRSLHSDHY SQHSAERLYR DSYPSKNSSL EKYPRKHQDA SFPAKAFSDK
     HGHSPSRSDW SPHDRSRYHE NRDRSPYARE RSPYIFEKSS HARKRSPRDR RHHDYRRSPS
     YSEWSPHDRS RPSDRRDYIP NFMEDTQSDR NRRNGHREIS RKSGVRERRD CQTGTELEIK
     HKYKESNGKE STSSSKELQG KNILYNNSLL VEKNSVCDSS KIPVPCATGK EPVQVGEAPT
     EELPSMEVDM DICDTPPHEP MASDSSLGKW FYLDYYGTEH GPARLSDLKA LMEQGILFSD
     HMIKHSDNNR WLVNPPEAPG NLLEDIADTT EAVCIEQGAG DSLPELVSVR TLPDGKEIFV
     ENREDFQIDM RVENLLDGRT ITPGREFETL GEALKVNVEF EETRRCVTSE GVVGMFRPMK
     RAIEEFKSDD AYGSESDEIG SWFSGRWSCK GGDWIRQDEA SQDRYYKKKI VLNDGFPLCL
     MQKSGHEDPR WHHKDDLYYP LSSSRLELPL WAFSVVDERN QTRGVKASLL SVVRLNSLVV
     NDQVPPIPDP RAKVRSKERC PSRPARPSPA SSDSKRESVE SHSQSTASTG QDSQGLWKTD
     TSVNTPRDRL CTVDDLQLHI GDWFYTDGAG QEQGPLSFSE LQKLVEKGFI KSHSSVFRKS
     DKIWVPVTSI TKSPETIAML RGKTPALPSA CQGLVVSETQ DFKYSEMDTS LNSFHGVHPQ
     FLGYFRGKLH QLVMKTFKSR DFSAAINDVV DSWIHARQPK KESEKYMYQS SELNSCYTKR
     ARLMAGESGE DSEMEDTQMF QKDELTFEDL CGDLTFNIEG NRSAGTVGIY WGLLDGHALA
     RVFHMLRYDV KSLAFASMTC RHWKATINSY KDISRQVDLS SLGPSCTDSR LRSIMNTYNK
     EKIDSIILVG CTNVTASMLE EILRLHPRIS SVDITGCSQF GDLTVNYKNV SWLRCQNTRS
     GELHSRIRSL KQTTDVAKSK GLGGDTDDFG NLKDYFDRVE KRDSANQLFR RSLYKRSKLY
     DARRSSAILS RDARIRRWAI KKSEHGYKRV EEFLASSLRG IMKQNTFDFF ALKVSQIEEK
     MKNGYYVSHG LRSVKEDISR MCREAIKDEL MKSWQDGSGL SSATKYNKKL SKTVAEKKYM
     SRTSDTFGVN GASDYGEYAS DREIKRRLSK LNRKSFSSES DTSSELSDNG KSDNYSSASA
     SESESDIRSE GRSQDLRIEK YFTADDSFDS VTEEREWGAR MTKASLVPPV TRKYEVIEKY
     AIVADEEEVQ RKMRVSLPED YGEKLNAQRN GIEELDMELP EVKEYKPRKL LGDEVLEQEV
     YGIDPYTHNL LLDSMPGELD WSLQDKHSFI EDVVLRTLNR QVRLFTGSGS TPMVFPLRPV
     IEELKESARE ECDIRTMKMC QGVLKEIESR SDDKYVSYRK GLGVVCNKEG GFGEEDFVVE
     FLGEVYPVWK WFEKQDGIRS LQENKTDPAP EFYNIYLERP KGDADGYDLV VVDAMHMANY
     ASRICHSCRP NCEAKVTAVD GHYQIGIYSV RAIEYGEEIT FDYNSVTESK EEYEASVCLC
     GSQVCRGSYL NLTGEGAFQK VLKDWHGLLE RHRLMLEACV LNSVSEEDYL ELGRAGLGSC
     LLGGLPDWMI AYSARLVRFI NFERTKLPEE ILKHNLEEKR KYFSDIHLDV EKSDAEVQAE
     GVYNQRLQNL AVTLDKVRYV MRHVFGDPKN APPPLERLTP EETVSFVWNG DGSLVDELLQ
     SLSPHLEEGP LNELRSKIHG HDPSGSADVL KELQRSLLWL RDEIRDLPCT YKCRNDAAAD
     LIHIYAYTKC FFKVREYQSF ISSPVHISPL DLGAKYADKL GESIKEYRKT YGENYCLGQL
     IYWYNQTNTD PDLTLVKATR GCLSLPDVAS FYAKAQKPSK HRVYGPKTVK TMVSQMSKQP
     QRPWPKDKIW TFKSTPRVFG SPMFDAVLNN SSSLDRELLQ WLRNRRHVFQ ATWDS
//
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