ID O25908_HELPY Unreviewed; 835 AA.
AC O25908;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=HP_1354 {ECO:0000313|EMBL:AAD08396.1};
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD08396.1, ECO:0000313|Proteomes:UP000000429};
RN [1] {ECO:0000313|EMBL:AAD08396.1, ECO:0000313|Proteomes:UP000000429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429};
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A.,
RA Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B.,
RA Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K.,
RA Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D.,
RA Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O.,
RA Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AE000511; AAD08396.1; -; Genomic_DNA.
DR PIR; B64689; B64689.
DR RefSeq; WP_010875614.1; NC_018939.1.
DR AlphaFoldDB; O25908; -.
DR STRING; 85962.HP_1354; -.
DR REBASE; 459105; HpyAORF1353P.
DR REBASE; 459106; HpyAXVIP.
DR REBASE; 56832; Hpy26695ORF6980P.
DR PaxDb; 85962-C694_06990; -.
DR EnsemblBacteria; AAD08396; AAD08396; HP_1354.
DR KEGG; hpy:HP_1354; -.
DR PATRIC; fig|85962.47.peg.1450; -.
DR eggNOG; COG0286; Bacteria.
DR InParanoid; O25908; -.
DR PhylomeDB; O25908; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AAD08396.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000429};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 298..494
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 721..827
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 835 AA; 96964 MW; 4E9AC9F7D4FAD2B6 CRC64;
MLKEYLESIK DLTPEKNELT HRPSLYNLLN QLKNHFNKEF KIEHEPERKQ GSQPDFRVSY
QGINIGYIEN KRAGTNLSQL LKSEKSDQIL KYLELNPNLM LTDYLNFMWV GKDENNEPLI
KKEISVASLD ELSKPLKPNP QTERDLIELF KSFFNHEAAP ITNAKDFATH LSPRTKYLKD
ALIKYQEKAQ VSSIFNNFKE YLYEELSFED FSDALAQTLT YSLFLAKLNH PSEKINLDNV
RSLIPKNFAV IREMADFLKK LDEIKEIQWL LNEILSSINH VDMDSILKDL NDDKDPYLHF
YETFLSTYDP KLRESKGVYY TPDSVVKFII NALDSLLKTH FKDAPLGLKS ALDNENIKLL
DFATGTGTFL LEAFRKALET RKTSDGGTST KEDKYQNLLK QFYGFEYLIA PYAIAHLNLS
QAFKEEFKKP LKENDALQII LTNTLIQPSE IIAYRGLSPI FEKELSNAQE IKKNENILII
TGNPPYSGAS ENKGLFEWEV KATYGIDPKF QTIEIEKNVK LADKIQTLLS SVQIQKQSGS
KNDLKKLKSL HSKYKLQDEK NPKWLLDDYV KFMRFAQNKI ESLGHGLFGF ISNNAFLDNP
TFRGLRRSLL ECYDELYILN LHGNARKKEK TPQGAKDENV FNIKQGVSIN LFVKNPQVVK
QKIHYYDVYG QRTEKYAFLA QNDLNSIEWL EIAPRGPFYL LLPLETPLLD EYEQGFSVQE
MFQIGSTGIC SQRDHVVFHK DKESLLKLLK DFSTLEPSEL RRIYNIKKDG RDWRLEYAIK
DVKANANNLE EYIVSCQYRP FDFYYTYYTG KSKSFIAYPR GEVFKHMLPP PPNKP
//
