ID O26587_METTH Unreviewed; 1157 AA.
AC O26587;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=DNA helicase related protein {ECO:0000313|EMBL:AAB84993.1};
GN OrderedLocusNames=MTH_487 {ECO:0000313|EMBL:AAB84993.1};
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420 {ECO:0000313|EMBL:AAB84993.1, ECO:0000313|Proteomes:UP000005223};
RN [1] {ECO:0000313|EMBL:AAB84993.1, ECO:0000313|Proteomes:UP000005223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H
RC {ECO:0000313|Proteomes:UP000005223};
RX PubMed=9371463;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-i., Rice P., Nolling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
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DR EMBL; AE000666; AAB84993.1; -; Genomic_DNA.
DR PIR; H69163; H69163.
DR RefSeq; WP_010876126.1; NC_000916.1.
DR AlphaFoldDB; O26587; -.
DR STRING; 187420.MTH_487; -.
DR PaxDb; 187420-MTH_487; -.
DR EnsemblBacteria; AAB84993; AAB84993; MTH_487.
DR GeneID; 1470448; -.
DR KEGG; mth:MTH_487; -.
DR PATRIC; fig|187420.15.peg.464; -.
DR HOGENOM; CLU_000788_1_0_2; -.
DR InParanoid; O26587; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR049468; Restrct_endonuc-II-like_dom.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18741; MTES_1575; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:AAB84993.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:AAB84993.1};
KW Hydrolase {ECO:0000313|EMBL:AAB84993.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AAB84993.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005223}.
FT DOMAIN 742..785
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 813..1004
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT DOMAIN 1047..1144
FT /note="Restriction endonuclease type II-like"
FT /evidence="ECO:0000259|Pfam:PF18741"
FT COILED 173..217
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1157 AA; 132525 MW; 9A19DFA211E1DCF1 CRC64;
MPSSPGGVSA YLKRVEGAVS SMEGWGVTDE VQLGFFSFTK FLMYMDLDPS SYPNWDEIVD
RPLLRALFSI EIDDDSEEVD IDSIPYRDLY HVVDADSSQI AVIEDVKAGK NLVVEGPPGT
GKSQTIVNLI AELMASGKTV LFVSEKMAAL EVVKSRLDSI GLGRFCLELH SHKARKKDVL
NELEATLMEA EADRPEAERE FRRMERLRDE LNEYRRALHE PLYSIQLSPF QLFGMKERAE
KYFNGELPFV RIPSPETITP DEWDEALVEL RNLAKLAELL PPLQENPWSG TDPGMMLPSD
VRELEILLES IMKTADRLTA SLREFQERYG FMRVKTPGEL RGLAEVVSVV AESRPFDLGV
LESSIWDRYR ADAFTLLDKL ESYTRKREIL DRFHESVHGV DLEALLRDYL KESSSRIKFL
SGRYRKIRNE IDALYVGRAP ENDYEVVEDL ENLMDVMSLR EELERYSGVA ERFFGSMWNP
ENPPLEDLRA TAEWIVRFRD LHSDGMISER TLECISRGLD GEKLLSEFEE IMEIYNELED
KLSRLQKGIN THAHVLFNSM PEDVPFRAWR SRVKAWSEAL NLLPLWSQYL EKKRLCMKTR
GAAFIPIIES GIIRMDDIRP AMEGNLADAL LERAFREIPT LYTFIGDLHE AKIREFRELD
SRIIELNRKR LIHQLNSNMP TVFGGAAPNS EESILSGEFT RKRGHMPLRK LLKLAGGTVK
RIKPCFMMSP LSIAQYLDPR SSQLQFDVVI FDEASQVKPE DALGAFLRAR TAVVMGDTNQ
LPPTSFFDQM ISAEEDSEDV ATAADIESIL HLCKRSFPVR MLRWHYRSRH ESLIAVSNQE
FYDNRLLVYP SPAREDEELG LHLVYLPDTV YERGRTSSNP LEAAAVVDAI EEHFMRYGSS
RSLGVGTFSV AQMNAILEAL EARLRENPEL ERIINQETDE PFFIKNLETI QGDERDVIFI
SVGYGFDERG RMSLNFGPLN QEGGERRLNV LITRAREKCV VFTNFRSSDL RTGPGTPFGV
RALKRFLRYA ETGFLESDST DTSQGLFEDS VYDFLVDAGF EVDRGVGCAG FRVDFAVKDP
DEPGRYIAGI LTDGEMYSRA EVARDRDRLR EEILRNLGWK IIHLWSSDWY RNREETQRKV
SDRLEEIVEE PVWPGVT
//
