ID O26642_METTH Unreviewed; 341 AA.
AC O26642;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 92.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=MTH_542 {ECO:0000313|EMBL:AAB85048.1};
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420 {ECO:0000313|EMBL:AAB85048.1, ECO:0000313|Proteomes:UP000005223};
RN [1] {ECO:0000313|EMBL:AAB85048.1, ECO:0000313|Proteomes:UP000005223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H
RC {ECO:0000313|Proteomes:UP000005223};
RX PubMed=9371463;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-i., Rice P., Nolling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the HerA family.
CC {ECO:0000256|ARBA:ARBA00007816}.
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DR EMBL; AE000666; AAB85048.1; -; Genomic_DNA.
DR PIR; F69171; F69171.
DR AlphaFoldDB; O26642; -.
DR STRING; 187420.MTH_542; -.
DR PaxDb; 187420-MTH_542; -.
DR EnsemblBacteria; AAB85048; AAB85048; MTH_542.
DR KEGG; mth:MTH_542; -.
DR PATRIC; fig|187420.15.peg.522; -.
DR HOGENOM; CLU_812848_0_0_2; -.
DR InParanoid; O26642; -.
DR Proteomes; UP000005223; Chromosome.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR018538; HerA_barrel_dom.
DR InterPro; IPR002789; HerA_central.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42957; HELICASE MJ1565-RELATED; 1.
DR PANTHER; PTHR42957:SF1; HELICASE MJ1565-RELATED; 1.
DR Pfam; PF01935; DUF87; 1.
DR Pfam; PF09378; HAS-barrel; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005223}.
FT DOMAIN 6..95
FT /note="Helicase HerA barrel"
FT /evidence="ECO:0000259|Pfam:PF09378"
FT DOMAIN 131..327
FT /note="Helicase HerA central"
FT /evidence="ECO:0000259|Pfam:PF01935"
SQ SEQUENCE 341 AA; 37821 MW; 6D8ED52696A8E6A7 CRC64;
MMETAGQIIG GETAAVLIRQ KAGEPIELGD LLVAEGEGYT ILQVKDLRYS SQIPQGMREL
ASGFNLEGYG REVELLEPEL RNYIIAEARP ILHVRDGQPM IPKRLPRFFR EVRRIREGDL
DFLERPGNPV FLGNVRSGSK VLDTPVYVDA VDAITHHILI PATTGRGKSN LVKVMLWSLA
EMDRVGILVL DPHDEYYGRN EAGLGRHPSD NVVYYSPDAP VGGNTLTINL RSLRPEHFEG
IIPFTQAQEQ AIARYYNEYG DGWILKIVEG EELPGVQPVT LNVLRRIFDV ILGVHLDDGK
IKSRGGVFRE RGGESTIKDI AASLEDGKNR CGGHLKAHGR G
//
