GenomeNet

Database: UniProt
Entry: O29871
LinkDB: O29871
Original site: O29871 
ID   ACDG_ARCFU              Reviewed;         470 AA.
AC   O29871;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   10-APR-2019, entry version 102.
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma {ECO:0000255|HAMAP-Rule:MF_01136};
DE            Short=ACDS complex subunit gamma {ECO:0000255|HAMAP-Rule:MF_01136};
DE            EC=2.1.1.245 {ECO:0000255|HAMAP-Rule:MF_01136};
DE   AltName: Full=5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase {ECO:0000255|HAMAP-Rule:MF_01136};
DE   AltName: Full=ACDS complex methyltransferase {ECO:0000255|HAMAP-Rule:MF_01136};
DE   AltName: Full=Corrinoid/iron-sulfur component large subunit {ECO:0000255|HAMAP-Rule:MF_01136};
GN   Name=cdhE {ECO:0000255|HAMAP-Rule:MF_01136};
GN   OrderedLocusNames=AF_0376;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM
OS   9628 / NBRC 100126).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales;
OC   Archaeoglobaceae; Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA   Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA   Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA   Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA   Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA   Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA   Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA   Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA   Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA   Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA   Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-
RT   reducing archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-19.
RC   STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
RX   PubMed=9575239; DOI=10.1007/s002030050606;
RA   Dai Y.R., Reed D.W., Millstein J.H., Hartzell P.L., Grahame D.A.,
RA   DeMoll E.;
RT   "Acetyl-CoA decarbonylase/synthase complex from Archaeoglobus
RT   fulgidus.";
RL   Arch. Microbiol. 169:525-529(1998).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage
CC       of acetyl-CoA, allowing autotrophic growth from CO(2).
CC       {ECO:0000255|HAMAP-Rule:MF_01136}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III)
CC         corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin +
CC         [Co(I) corrinoid Fe-S protein] + H(+); Xref=Rhea:RHEA:45196,
CC         Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:59924, ChEBI:CHEBI:64267, ChEBI:CHEBI:85033,
CC         ChEBI:CHEBI:85035; EC=2.1.1.245; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01136};
CC   -!- COFACTOR:
CC       Name=corrinoid; Xref=ChEBI:CHEBI:33913;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01136};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01136};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000255|HAMAP-Rule:MF_01136};
CC   -!- SUBUNIT: Heterodimer of delta and gamma chains. The ACDS complex
CC       is made up of alpha, epsilon, beta, gamma and delta chains with a
CC       probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-
CC       (gamma(1)delta(1))(8). {ECO:0000255|HAMAP-Rule:MF_01136}.
DR   EMBL; AE000782; AAB90860.1; -; Genomic_DNA.
DR   PIR; H69296; H69296.
DR   RefSeq; WP_010877883.1; NC_000917.1.
DR   ProteinModelPortal; O29871; -.
DR   SMR; O29871; -.
DR   STRING; 224325.AF_0376; -.
DR   PRIDE; O29871; -.
DR   DNASU; 1483591; -.
DR   EnsemblBacteria; AAB90860; AAB90860; AF_0376.
DR   GeneID; 24793915; -.
DR   KEGG; afu:AF_0376; -.
DR   eggNOG; arCOG01979; Archaea.
DR   eggNOG; COG1456; LUCA.
DR   KO; K00197; -.
DR   OMA; SCMAFAT; -.
DR   OrthoDB; 31154at2157; -.
DR   BRENDA; 2.1.1.245; 414.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046356; P:acetyl-CoA catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.20; -; 1.
DR   HAMAP; MF_01136; CdhE; 1.
DR   InterPro; IPR007202; 4Fe-4S_dom.
DR   InterPro; IPR016041; Ac-CoA_synth_d_su_TIM-brl.
DR   InterPro; IPR016218; AcylCoA_decarb/synth_gsu.
DR   InterPro; IPR023427; AcylCoA_decarb/synth_gsu_arc.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   Pfam; PF03599; CdhD; 1.
DR   Pfam; PF04060; FeS; 1.
DR   PIRSF; PIRSF000376; AcCoA_decarb_gamma; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   PROSITE; PS51656; 4FE4S; 1.
PE   1: Evidence at protein level;
KW   4Fe-4S; Cobalt; Complete proteome; Direct protein sequencing; Iron;
KW   Iron-sulfur; Metal-binding; Methyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN         1    470       Acetyl-CoA decarbonylase/synthase complex
FT                                subunit gamma.
FT                                /FTId=PRO_0000155118.
FT   DOMAIN        1     62       4Fe-4S. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00989}.
FT   METAL        18     18       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_01136}.
FT   METAL        21     21       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_01136}.
FT   METAL        26     26       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_01136}.
FT   METAL        43     43       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_01136}.
SQ   SEQUENCE   470 AA;  52551 MW;  0BEC4537F265CA3A CRC64;
     MKVKSPLEVY NYLPRTNCGE CGFDTCMSFA AHILDRSVTP LDCKPLVRDA EKDPKVKKKL
     EELLELTAPE IAEVVIGVGE NAVKIGGEEV LHRHELTFFN PTGFFYDVWD TMDDKALEER
     CDRVVSYKKF YVGNFLTLDG FAVRCTSGDP KRYREVVKKV ASYGKPLILV ALDSECMKAA
     LEEVADQRPL MYAATEGNWK EFLKLALEYK VPVTLRAKDL DLLKSMAVTF KQAGVKDIVL
     DPVTEPLGEG LKGTFERVIQ LRRTAIAGQD KDVAYPIMIT PIAAWLIEGD DVTKSYWEAV
     IASIFIVKYG DVMIFRSIDQ HVVMPTITLR FNIYTDPRTP VQVEPGLRAI NDPGPDDPVF
     ITTNFALTYY TVESDLTSGG IKGWLLVLNT EGLGVEVSVA GGQFTASKVK ELIEETKIEE
     KVNHRYLVIP GLAARLQGAI EDETGWKVLV GPMDSGRIKG WLEKNWPPKE
//
DBGET integrated database retrieval system