ID O29881_ARCFU Unreviewed; 681 AA.
AC O29881;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Acetyl-CoA synthetase (Acs-2) {ECO:0000313|EMBL:AAB90867.1};
GN OrderedLocusNames=AF_0366 {ECO:0000313|EMBL:AAB90867.1};
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325 {ECO:0000313|EMBL:AAB90867.1, ECO:0000313|Proteomes:UP000002199};
RN [1] {ECO:0000313|EMBL:AAB90867.1, ECO:0000313|Proteomes:UP000002199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16
RC {ECO:0000313|Proteomes:UP000002199};
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.P., Clayton R.A., Tomb J., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B., Peterson S.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L., Utterback T., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
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DR EMBL; AE000782; AAB90867.1; -; Genomic_DNA.
DR PIR; F69295; F69295.
DR RefSeq; WP_010877873.1; NC_000917.1.
DR AlphaFoldDB; O29881; -.
DR STRING; 224325.AF_0366; -.
DR PaxDb; 224325-AF_0366; -.
DR EnsemblBacteria; AAB90867; AAB90867; AF_0366.
DR GeneID; 24793906; -.
DR KEGG; afu:AF_0366; -.
DR eggNOG; arCOG04201; Archaea.
DR HOGENOM; CLU_000022_3_6_2; -.
DR OrthoDB; 371752at2157; -.
DR PhylomeDB; O29881; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF232; ACETYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002199}.
FT DOMAIN 31..88
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 96..492
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 556..635
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 681 AA; 77587 MW; 8C3D67FB023A11E9 CRC64;
MADPMEAMKK EFENRIIPPS WKDRVWEIED YRKFHEDTIK DKESIEKWWE KWANEIFWFR
KWDRALDDSN PPFYRWFVGG ETNLAYLCTD WQIEQGRKNK VAIIWEGEPV KENGEPVEVR
KLTYYDLYRE SNRIAAMLKD KLGVKKDEIL TFYLPMIPEL PLFMLGVQRI GAKHSIVFSG
FSAQALAVRI MDAGARYVVT ADGVYRRGKV LNLKAIVDDA VKICEQEGHK VEKVIVVKRA
GNEIPWNDSR DVWFEDLMAD IGKNVKVECE KMGSEDFSFI LYTSGTTGRP KGAQHSVGGY
AVHLYTTMKL IFDIKDDDIF WCTADIGWIT GHSYIVYGPL MCGATTMMYE GAPDFPDVSR
WAAMIERYGV TIFYTAPTAI RMLMRFPEEN YTKYDMSTLR IIHSVGEPIN PEAWRWYYRV
FGREDVVCSS TWWMTETGGM LTDHFPGLGK IIPLKPGTNG YPIPGVRMEV LDDEGNSVKP
GERGYLVIST PWPGMLMTLF KDPNRFIDVY FGKYKSKGWY YYTGDFAMFD EDGYVWVLGR
ADDILKVAGH RIGTAEIESA MVSHPDVAEA ACVGKSDPVK GEIPIIYVVL REGVEPSPDM
VNELKKHLRA TLGPVVASDA VITFVNTLPK TRSGKIMRRL LRAVAEGKEL GDVTTLESEV
AVEEAKKAYE MVKAALEGSK S
//
