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Database: UniProt
Entry: O34815
LinkDB: O34815
Original site: O34815 
ID   YOAD_BACSU              Reviewed;         344 AA.
AC   O34815; Q796G0;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JAN-2019, entry version 115.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase YoaD;
DE            EC=1.1.1.-;
GN   Name=yoaD; OrderedLocusNames=BSU18560;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich D.;
RT   "Sequence analysis of the Bacillus subtilis chromosome region between
RT   the terC and odhAB loci cloned in a yeast artificial chromosome.";
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INDUCTION, AND OPERON STRUCTURE.
RC   STRAIN=168;
RX   PubMed=12193636; DOI=10.1128/JB.184.18.5179-5186.2002;
RA   Auger S., Danchin A., Martin-Verstraete I.;
RT   "Global expression profile of Bacillus subtilis grown in the presence
RT   of sulfate or methionine.";
RL   J. Bacteriol. 184:5179-5186(2002).
CC   -!- INDUCTION: Induced by sulfate, part of the yoaDCB operon.
CC       {ECO:0000269|PubMed:12193636}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; AF027868; AAB84446.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13749.1; -; Genomic_DNA.
DR   PIR; F69895; F69895.
DR   RefSeq; NP_389738.1; NC_000964.3.
DR   RefSeq; WP_009967372.1; NZ_JNCM01000036.1.
DR   ProteinModelPortal; O34815; -.
DR   SMR; O34815; -.
DR   STRING; 224308.Bsubs1_010100010221; -.
DR   PaxDb; O34815; -.
DR   PRIDE; O34815; -.
DR   EnsemblBacteria; CAB13749; CAB13749; BSU18560.
DR   GeneID; 940109; -.
DR   KEGG; bsu:BSU18560; -.
DR   PATRIC; fig|224308.179.peg.2023; -.
DR   eggNOG; ENOG4108M3J; Bacteria.
DR   eggNOG; COG0111; LUCA.
DR   HOGENOM; HOG000136700; -.
DR   InParanoid; O34815; -.
DR   KO; K00058; -.
DR   OMA; CRGMPSN; -.
DR   PhylomeDB; O34815; -.
DR   BioCyc; BSUB:BSU18560-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IBA:GO_Central.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    344       Putative 2-hydroxyacid dehydrogenase
FT                                YoaD.
FT                                /FTId=PRO_0000386538.
FT   ACT_SITE    251    251       {ECO:0000255}.
FT   ACT_SITE    280    280       {ECO:0000255}.
FT   ACT_SITE    300    300       Proton donor. {ECO:0000255}.
FT   BINDING     193    193       NAD. {ECO:0000255}.
FT   BINDING     275    275       NAD. {ECO:0000255}.
SQ   SEQUENCE   344 AA;  38630 MW;  4FE6916A4CA224F8 CRC64;
     MKNTMKRMFC SMTVLVTAPY NEEGRKELEN LFGSVAYQSW KEQGRAYRED ELIQLLKATN
     ATGLITELDQ VTDSVFASVP ELSFVGVCRG MPSNVDVAAA SKRGIPVFYT PGRNAQAVAE
     MFIGNVISFL RHTSASNQWL KDGEWDSDYL QAYVKFKGNE LTGKTVGMIG FGAVGQRIAK
     LLTAFDCKIK YYDPYIQDDH PLYEKASLKT VFSDSDIVSV HLPRTEETLG LIDRQYFDLM
     KESAIFVNTS RAVVVNREDL LFVLKEHKIS GAILDVFYHE PPEESDYELI SLPNVLATPH
     LAGATFEVED HHVTILNKAL KKWKGEKTLN IQTMYNKDAL KTGG
//
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