ID LRC23_MOUSE Reviewed; 340 AA.
AC O35125;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE RecName: Full=Leucine-rich repeat-containing protein 23;
DE AltName: Full=Leucine-rich protein B7;
GN Name=Lrrc23; Synonyms=Lrpb7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9445485;
RA Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J.,
RA Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A.;
RT "Comparative sequence analysis of a gene-rich cluster at human chromosome
RT 12p13 and its syntenic region in mouse chromosome 6.";
RL Genome Res. 8:29-40(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AC002397; AAC36001.1; -; Genomic_DNA.
DR EMBL; BC049601; AAH49601.1; -; mRNA.
DR CCDS; CCDS20528.1; -.
DR RefSeq; NP_001289484.1; NM_001302555.1.
DR RefSeq; XP_006505722.1; XM_006505659.3.
DR RefSeq; XP_006505723.1; XM_006505660.3.
DR RefSeq; XP_006505726.1; XM_006505663.3.
DR RefSeq; XP_011239541.1; XM_011241239.2.
DR RefSeq; XP_011239542.1; XM_011241240.2.
DR AlphaFoldDB; O35125; -.
DR SMR; O35125; -.
DR STRING; 10090.ENSMUSP00000032218; -.
DR PhosphoSitePlus; O35125; -.
DR SwissPalm; O35125; -.
DR MaxQB; O35125; -.
DR PaxDb; 10090-ENSMUSP00000032218; -.
DR ProteomicsDB; 252668; -.
DR Antibodypedia; 35084; 110 antibodies from 19 providers.
DR Ensembl; ENSMUST00000032218.10; ENSMUSP00000032218.4; ENSMUSG00000030125.12.
DR Ensembl; ENSMUST00000112475.9; ENSMUSP00000108094.3; ENSMUSG00000030125.12.
DR GeneID; 16977; -.
DR KEGG; mmu:16977; -.
DR UCSC; uc009drv.2; mouse.
DR AGR; MGI:1315192; -.
DR CTD; 10233; -.
DR MGI; MGI:1315192; Lrrc23.
DR VEuPathDB; HostDB:ENSMUSG00000030125; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000159748; -.
DR HOGENOM; CLU_056804_1_1_1; -.
DR InParanoid; O35125; -.
DR OMA; NPCTDES; -.
DR OrthoDB; 1330382at2759; -.
DR PhylomeDB; O35125; -.
DR TreeFam; TF329158; -.
DR BioGRID-ORCS; 16977; 1 hit in 79 CRISPR screens.
DR PRO; PR:O35125; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; O35125; Protein.
DR Bgee; ENSMUSG00000030125; Expressed in spermatocyte and 76 other cell types or tissues.
DR ExpressionAtlas; O35125; baseline and differential.
DR Genevisible; O35125; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF10; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 23; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 6.
PE 1: Evidence at protein level;
KW Coiled coil; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..340
FT /note="Leucine-rich repeat-containing protein 23"
FT /id="PRO_0000264237"
FT REPEAT 89..110
FT /note="LRR 1"
FT REPEAT 111..134
FT /note="LRR 2"
FT REPEAT 177..197
FT /note="LRR 3"
FT REPEAT 198..219
FT /note="LRR 4"
FT REPEAT 220..241
FT /note="LRR 5"
FT REPEAT 243..264
FT /note="LRR 6"
FT DOMAIN 277..315
FT /note="LRRCT"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 305..328
FT /evidence="ECO:0000255"
FT COMPBIAS 1..23
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 39292 MW; AD81FFB8D96AA650 CRC64;
MSDEDDVDDV DAEQDEVESD KEIEEWEDYR KETEEASEEW LPTPITEAMM KEGLSLLCKI
GSGLAHAYIK LEAKDRDLTD ISLLRSYIHL RYVDISENHI TDISPLNSLT HLLWLKADGN
QLRSARMNEL PYLQIASFSY NQIIDTEGIF HPRLGSLDLK GNRIHQVTGL DPERLSSLHT
LELRGNQLES TKGIYLPKLK NLYLAQNLLK KVEGLENLSN LTTLHLRDNQ IETLNGFSQE
MKSLQYLNLR SNMISDLAEL AKLRDLPKLR ALVLLDNPCA DETDYRQEAL VQMAHLERLD
KEFYEDDDRA EAEEIRQRLK EEQDQDLDPD QDMEPYLPPV
//
