ID O35424_MOUSE Unreviewed; 271 AA.
AC O35424;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 191.
DE SubName: Full=Histocompatibility 2, O region beta locus {ECO:0000313|Ensembl:ENSMUSP00000092985.4};
DE SubName: Full=IAbeta2 subunit {ECO:0000313|EMBL:AAB81530.1};
GN Name=H2-Ob {ECO:0000313|Ensembl:ENSMUSP00000092985.4,
GN ECO:0000313|MGI:MGI:95925};
GN Synonyms=H2-IAbeta2 {ECO:0000313|EMBL:AAB81530.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAB81530.1};
RN [1] {ECO:0000313|EMBL:AAB81530.1}
RP NUCLEOTIDE SEQUENCE.
RA Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G.,
RA Hood L.;
RT "Sequence of the mouse major histocompatibility locus class II region.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000092985.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092985.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000092985.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092985.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|ARBA:ARBA00007394}.
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DR EMBL; AF027865; AAB81530.1; -; Genomic_DNA.
DR PIR; A23884; A23884.
DR RefSeq; NP_034519.2; NM_010389.3.
DR STRING; 10090.ENSMUSP00000092985; -.
DR PaxDb; 10090-ENSMUSP00000092985; -.
DR ProteomicsDB; 342773; -.
DR Antibodypedia; 34891; 223 antibodies from 24 providers.
DR DNASU; 15002; -.
DR Ensembl; ENSMUST00000095342.11; ENSMUSP00000092985.4; ENSMUSG00000041538.17.
DR GeneID; 15002; -.
DR KEGG; mmu:15002; -.
DR UCSC; uc008cca.1; mouse.
DR AGR; MGI:95925; -.
DR CTD; 15002; -.
DR MGI; MGI:95925; H2-Ob.
DR VEuPathDB; HostDB:ENSMUSG00000041538; -.
DR eggNOG; ENOG502RWX2; Eukaryota.
DR GeneTree; ENSGT00940000162353; -.
DR HOGENOM; CLU_047501_13_1_1; -.
DR OMA; ASVNMIC; -.
DR OrthoDB; 3785866at2759; -.
DR TreeFam; TF336626; -.
DR BioGRID-ORCS; 15002; 1 hit in 79 CRISPR screens.
DR ChiTaRS; H2-Ob; mouse.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000041538; Expressed in peripheral lymph node and 61 other cell types or tissues.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; ISO:MGI.
DR GO; GO:0042613; C:MHC class II protein complex; ISO:MGI.
DR GO; GO:0023026; F:MHC class II protein complex binding; ISO:MGI.
DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002587; P:negative regulation of antigen processing and presentation of peptide antigen via MHC class II; ISO:MGI.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR PANTHER; PTHR19944:SF43; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Proteomics identification {ECO:0007829|EPD:O35424,
KW ECO:0007829|MaxQB:O35424};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..271
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015096771"
FT TRANSMEM 225..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..213
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 271 AA; 30464 MW; A0F324D82564A4AA CRC64;
MGAGRAPWVV ALLVNLMRLD SFMIEGRDSP ENFVIQAKAD CYFTNGTEKV HLLVRFIFNL
EEYLHFDSDL GMFVALTELG EPDADQWNKR LDLLETSRAA VNMVCRQKYK LGAPFTVERN
VPPEVTVYPE RTPLLQQHNL LLCSVTGFYP GDISVKWFRN GQEERSGVMS TGLVRNGDWT
FQTTVMLEMI PELGDIYSCL VEHPGLLRPV SVAWMAQSEY SWKKILSGAA VFLLGLIVFL
VGVVIHLKAQ KASVETQPGN EASRESLHSQ P
//
