ID CP1A1_SPAAU Reviewed; 521 AA.
AC O42457; O42458;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Cytochrome P450 1A1;
DE EC=1.14.14.1;
DE AltName: Full=CYPIA1;
GN Name=cyp1a1;
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Cousinou M., Lopez-Barea J., Dorado G.;
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 175-521.
RC TISSUE=Liver;
RA Tom M.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC They oxidize a variety of structurally unrelated compounds, including
CC steroids, fatty acids, and xenobiotics.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC ChEBI:CHEBI:142491; EC=1.14.14.1;
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC membrane protein. Microsome membrane; Peripheral membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AF011223; AAB64297.1; -; mRNA.
DR EMBL; AF005719; AAB62887.1; -; mRNA.
DR AlphaFoldDB; O42457; -.
DR SMR; O42457; -.
DR Ensembl; ENSSAUT00010060013.1; ENSSAUP00010057154.1; ENSSAUG00010023400.1.
DR GeneTree; ENSGT00950000183037; -.
DR InParanoid; O42457; -.
DR OMA; DPRAYWQ; -.
DR OrthoDB; 2900138at2759; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0006725; P:cellular aromatic compound metabolic process; IEA:Ensembl.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR CDD; cd20676; CYP1A; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24289:SF18; CYTOCHROME P450 1A2; 1.
DR PANTHER; PTHR24289; STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01683; EP450ICYP1A.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW Monooxygenase; Oxidoreductase; Reference proteome.
FT CHAIN 1..521
FT /note="Cytochrome P450 1A1"
FT /id="PRO_0000051647"
FT BINDING 229
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 463
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT CONFLICT 175..177
FT /note="LVK -> GTR (in Ref. 2; AAB62887)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="G -> A (in Ref. 2; AAB62887)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="Y -> S (in Ref. 2; AAB62887)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 521 AA; 59122 MW; 8FE00D86460B303B CRC64;
MVLMILPFVG PVSVSESLVA IITMCLVYMI LKFFRTEIPE GLCQLPGPKP LPIIGNVLEV
GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA LIKQGDDFAG RPDLYSFRFI
NDGKSLAFST DQAGVWRARR KLAYSALRSF STLEGTTPEY SCALEEHVSK EAEYLVKQLN
TVMETDGSFD PFRHIVVSVA NVICGMCFGR RYDHNNQELL NLVNLSDEFG QVVASGNPAD
FIPILQYLPS TSMKKFVSIN DRFNAFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD
ENSNVQMSDE KVVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ EMKESVGLDR
TPCLSDKPKL PFLEAFILEI FRHSSFLPFT IPHCSSKDTS LNGYFIPKDT CVFINQWQIN
HDPELWKDPS SFNPDRFLNT DGTELNKLEG EKMMVFGLGK RRCIGEVIAR NEVFLFLAIL
VQNLRFHAKP GEPLDMTPEY GLTMKHKRCH LRAAMRSRNE E
//
