ID O42484_CHICK Unreviewed; 735 AA.
AC O42484; E1BW32;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 163.
DE SubName: Full=17-beta-hydroxysteroid dehydrogenase type IV {ECO:0000313|EMBL:AAC60249.1};
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 4 {ECO:0000313|Ensembl:ENSGALP00010012678.1};
GN Name=HSD17B4 {ECO:0000313|Ensembl:ENSGALP00010012678.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAC60249.1};
RN [1] {ECO:0000313|EMBL:AAC60249.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9245902; DOI=10.1006/exer.1996.0262;
RA Kobayashi K., Kobayashi H., Ueda M., Honda Y.;
RT "Expression of 17 beta-hydroxysteroid dehydrogenase type IV in chick
RT retinal pigment epithelium.";
RL Exp. Eye Res. 64:719-726(1997).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010012678.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010012678.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; U77911; AAC60249.1; -; mRNA.
DR RefSeq; NP_990274.1; NM_204943.1.
DR STRING; 9031.ENSGALP00000003418; -.
DR PaxDb; 9031-ENSGALP00000003418; -.
DR Ensembl; ENSGALT00010022105.1; ENSGALP00010012678.1; ENSGALG00010009280.1.
DR GeneID; 395785; -.
DR KEGG; gga:395785; -.
DR CTD; 3295; -.
DR VEuPathDB; HostDB:geneid_395785; -.
DR eggNOG; ENOG502QPX4; Eukaryota.
DR GeneTree; ENSGT00940000158343; -.
DR HOGENOM; CLU_010194_18_4_1; -.
DR OMA; WATKVHT; -.
DR OrthoDB; 2140828at2759; -.
DR Reactome; R-GGA-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-GGA-2046106; alpha-linolenic acid (ALA) metabolism.
DR Reactome; R-GGA-389887; Beta-oxidation of pristanoyl-CoA.
DR Reactome; R-GGA-390247; Beta-oxidation of very long chain fatty acids.
DR Reactome; R-GGA-9033241; Peroxisomal protein import.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000002187; Expressed in kidney and 13 other cell types or tissues.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0044594; F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0018812; F:3-hydroxyacyl-CoA dehydratase activity; IEA:Ensembl.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IBA:GO_Central.
DR GO; GO:0004303; F:estradiol 17-beta-dehydrogenase [NAD(P)] activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
DR GO; GO:0008210; P:estrogen metabolic process; IEA:Ensembl.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR GO; GO:0036112; P:medium-chain fatty-acyl-CoA metabolic process; IEA:Ensembl.
DR GO; GO:0060009; P:Sertoli cell development; IEA:Ensembl.
DR GO; GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Ensembl.
DR GO; GO:0036111; P:very long-chain fatty-acyl-CoA metabolic process; IEA:Ensembl.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Proteomics identification {ECO:0007829|PeptideAtlas:O42484};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 482..598
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 627..730
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 735 AA; 80149 MW; 6D24AD4C7CC5179D CRC64;
MAAGLRFDGR VVLVTGAGGG LGRAYALAFA ERGASVVVND LGGDFKGYGK SSSAADKVVS
EIRANGGKAV PNYDSVEDGE KLVKSALEAF GRIDIVINNA GILRDRSFVR ISDEDWDIIH
RIHLRGSFLV TRAAWNHMKN QKFGRIIMTS SAAGIYGNFG QANYSAAKLG LLGLSNTIAI
EGRKYNIHCN TIAPTAGSRL TQTVMPQDLI DAFKPEYVAP LVLWLCHETC MENGSLFEVG
AGWIGKLRWE RSLGAIVRGK DQPMTPEAVR DKWEKVCDFN NASKPRSIQE SISVLNDALS
QIESQGSISM NSTNSRSVVS SAVDTTSLVG RELTTKVYKY THLEPILYAL GVGMSTKDPD
HLKFLFEGSE EFCCLPTFGV IPAQTSMFDG VPSIPGLDMD LAKMLHGEQY LELYKPLPTS
GELRSVSTIA DLLDKGSGAV LLIDVNTYCG KDLVCYNQFS LFFVGAGGFG GKRTSEKAKV
TVNPPKRPPD AILSDVTTSD QAALYRLSGD WNPLHLDPSF AALGGFQKPI LHGLCTFGFA
ARNVLKQFAN NDVTRFKAIK VRFAKPVFPG QTLQTEMWKE GNRIHFQTKV KETGDLAIAG
GYVDIVSALD KPSALEPTAG LQSDLVFEEI GRRIKEVGHE LVRKVNAVFQ WDITKDGKTA
VQWTIDLKNG SGSVYQGPAR SSADTTFTLS DQDFMDVVQK KTNPQKAFFS GKLKVKGNIM
LSQKLEMILK DYAKL
//
