ID O44196_CAEEL Unreviewed; 503 AA.
AC O44196;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 2.
DT 27-MAR-2024, entry version 130.
DE SubName: Full=SLC41A/MgtE integral membrane domain-containing protein {ECO:0000313|EMBL:CCD70160.1};
GN ORFNames=CELE_ZK185.2 {ECO:0000313|EMBL:CCD70160.1}, ZK185.2
GN {ECO:0000313|EMBL:CCD70160.1, ECO:0000313|WormBase:ZK185.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70160.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70160.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70160.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749}.
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DR EMBL; BX284604; CCD70160.1; -; Genomic_DNA.
DR PIR; T32564; T32564.
DR RefSeq; NP_500586.2; NM_068185.7.
DR AlphaFoldDB; O44196; -.
DR SMR; O44196; -.
DR STRING; 6239.ZK185.2.1; -.
DR TCDB; 1.A.26.2.4; the mg(2+) transporter-e (mgte) family.
DR PaxDb; 6239-ZK185-2; -.
DR EnsemblMetazoa; ZK185.2.1; ZK185.2.1; WBGene00022682.
DR GeneID; 177221; -.
DR KEGG; cel:CELE_ZK185.2; -.
DR UCSC; ZK185.2; c. elegans.
DR AGR; WB:WBGene00022682; -.
DR WormBase; ZK185.2; CE31747; WBGene00022682; -.
DR eggNOG; KOG3788; Eukaryota.
DR GeneTree; ENSGT00950000183042; -.
DR HOGENOM; CLU_018207_3_0_1; -.
DR InParanoid; O44196; -.
DR OMA; CFWSQWK; -.
DR OrthoDB; 5124745at2759; -.
DR PhylomeDB; O44196; -.
DR Reactome; R-CEL-425410; Metal ion SLC transporters.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00022682; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF21; PROTEIN CBG01705; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..258
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 336..478
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
SQ SEQUENCE 503 AA; 55106 MW; 1EC2600FFB99D0A5 CRC64;
MSNEHDDFEP IDGVMEAQIP QSTTIDHLIV EGNNNQNNNH NTGDTLSNVI VENWIFAPIA
VTIQKMNVSK TNHVFNVAEK ESKKQFLAEA LIPFLFAGLG LILAGVMLES AEGSEFFTTL
PDAVIMVPTL VGLKGNLEMT LSSRLSTLAN LGFMESRKDK INVALSNMAL IQCQAIAVSS
LAVIPVLFLG EQAISFDDTL CLLLSAVVTA SLASLVLSLL MVAVVIAARR WKLNPDNIST
PVAASLGDVS TLYILLTVGT LACHMRDLHV TLLIVILLFF YAIAIVGAVM AAEDRFTLEV
LKNGWWPILC AMMITTFSGL VLKKSMQTYP PLAAFQPLIN GLGGNLVAVQ ASRISTQLHR
ARKNREIEVR SLQTYINPWR AFFGNNEDAS AAQILLGISV PSNIIFIFII FLFGVGFHNT
TPFTISFVLV CAIQVTTLLY ICQILVRAMW IMRIDPDNSA IPFLTALGDL IGSLLLILCF
WSQWKYFGLP VSADQYTGHK FGH
//
