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Database: UniProt
Entry: O46040
LinkDB: O46040
Original site: O46040 
ID   MSTAA_DROME             Reviewed;         462 AA.
AC   O46040; O46041; Q9UB82;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 3.
DT   16-JAN-2019, entry version 131.
DE   RecName: Full=SET domain-containing protein SmydA-8, isoform A {ECO:0000305};
DE            EC=2.1.1.- {ECO:0000255|PROSITE-ProRule:PRU00190};
GN   Name=SmydA-8 {ECO:0000312|FlyBase:FBgn0053548};
GN   Synonyms=Msta {ECO:0000312|FlyBase:FBgn0053548};
GN   ORFNames=CG33548 {ECO:0000312|FlyBase:FBgn0053548};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000312|EMBL:AAN09072.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head;
RX   PubMed=10779958;
RA   Alatortsev V.E., Kovalenko T.A., Kalmykova A.I.;
RT   "Local duplication of genes with insertion of a complex
RT   microsatellite.";
RL   Mol. Biol. (Mosk.) 34:300-303(2000).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oregon-R;
RX   PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA   Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D.,
RA   Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E.,
RA   Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D.,
RA   Minana B., Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S.,
RA   Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B.,
RA   Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F.,
RA   Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A.,
RA   Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA   McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA   Glover D.M.;
RT   "From sequence to chromosome: the tip of the X chromosome of D.
RT   melanogaster.";
RL   Science 287:2220-2222(2000).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=O46040-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P83501-1; Sequence=External;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA15694.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AJ238707; CAB42051.1; -; mRNA.
DR   EMBL; AE014298; AAN09072.1; -; Genomic_DNA.
DR   EMBL; AL009193; CAA15694.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001014717.1; NM_001014717.2. [O46040-1]
DR   RefSeq; NP_001284812.1; NM_001297883.1. [O46040-1]
DR   ProteinModelPortal; O46040; -.
DR   BioGrid; 57739; 2.
DR   IntAct; O46040; 9.
DR   STRING; 7227.FBpp0070406; -.
DR   PaxDb; O46040; -.
DR   PRIDE; O46040; -.
DR   EnsemblMetazoa; FBtr0070422; FBpp0070406; FBgn0053548. [O46040-1]
DR   EnsemblMetazoa; FBtr0345599; FBpp0311668; FBgn0053548. [O46040-1]
DR   GeneID; 31200; -.
DR   KEGG; dme:Dmel_CG33548; -.
DR   UCSC; CG33548-RA; d. melanogaster. [O46040-1]
DR   CTD; 31200; -.
DR   FlyBase; FBgn0053548; SmydA-8.
DR   eggNOG; KOG2084; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   InParanoid; O46040; -.
DR   OMA; GTQHRII; -.
DR   PhylomeDB; O46040; -.
DR   GenomeRNAi; 31200; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0053548; Expressed in 14 organ(s), highest expression level in head.
DR   ExpressionAtlas; O46040; baseline and differential.
DR   Genevisible; O46040; DM.
DR   GO; GO:0000790; C:nuclear chromatin; ISS:FlyBase.
DR   GO; GO:0042826; F:histone deacetylase binding; ISS:FlyBase.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; ISS:FlyBase.
DR   GO; GO:0034968; P:histone lysine methylation; ISS:FlyBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:FlyBase.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    462       SET domain-containing protein SmydA-8,
FT                                isoform A.
FT                                /FTId=PRO_0000096607.
FT   DOMAIN       55    287       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   CONFLICT     76     76       A -> S (in Ref. 1; CAB42051).
FT                                {ECO:0000305}.
SQ   SEQUENCE   462 AA;  52157 MW;  04E956E80BC86416 CRC64;
     MSTAAQCPPP RPGGGGGDTT LAALSAHMAP CRDTTPEQLA QLIDVHLGDL RQEQPNWTIS
     SSTVAGRGVF ATRDIAAGEL IFQERALVTG PTARKGQLSS CICCHETLPQ TGFLCRHRCT
     LPVCETCSDS EEHQAECEHF RRWQPKDVDA EQEQVNPMSL RILTAVRVFH LGKEQRHLVD
     AMQANAERAY RREIIQAAQC FRNFPTTDRV FMDQLFRIVG VLNTNAFEAP CRSGGHETLL
     RGLFPLTAIM NHECTPNASH YFENGRLAVV RAARDIPKGG EITTTYTKIL WGNLTRNIFL
     KMTKHFACDC VRCHDNTENG TYLSALFCRE QGCRGLVIPV QTRTLQPDWR CITCENVFPH
     AKMAKYQDFA LNTINNRINS CSVQDMIHFI NELCPRFCPS SNYVLIEAKL NVIWRMTRFD
     HEEYTPEEMG HMDRYREEVL AILHKLGAGE CTLKKLITGE IQ
//
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