ID O51319_BORBU Unreviewed; 698 AA.
AC O51319;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 2.
DT 27-MAR-2024, entry version 144.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=BB_0344 {ECO:0000313|EMBL:AAC66713.2};
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borreliella.
OX NCBI_TaxID=224326 {ECO:0000313|EMBL:AAC66713.2, ECO:0000313|Proteomes:UP000001807};
RN [1] {ECO:0000313|EMBL:AAC66713.2, ECO:0000313|Proteomes:UP000001807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680
RC {ECO:0000313|Proteomes:UP000001807};
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R., Lathigra R.,
RA White O., Ketchum K.A., Dodson R., Hickey E.K., Gwinn M., Dougherty B.,
RA Tomb J.F., Fleischmann R.D., Richardson D., Peterson J., Kerlavage A.R.,
RA Quackenbush J., Salzberg S., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J., Weidman J., Utterback T., Watthey L., McDonald L., Artiach P.,
RA Bowman C., Garland S., Fuji C., Cotton M.D., Horst K., Roberts K.,
RA Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; AE000783; AAC66713.2; -; Genomic_DNA.
DR RefSeq; NP_212478.2; NC_001318.1.
DR RefSeq; WP_010889732.1; NC_001318.1.
DR AlphaFoldDB; O51319; -.
DR STRING; 224326.BB_0344; -.
DR PaxDb; 224326-BB_0344; -.
DR EnsemblBacteria; AAC66713; AAC66713; BB_0344.
DR KEGG; bbu:BB_0344; -.
DR PATRIC; fig|224326.49.peg.740; -.
DR HOGENOM; CLU_004585_5_5_12; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000001807; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001807}.
FT DOMAIN 10..280
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 281..545
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 698 AA; 81599 MW; 062D0676CE99B1F4 CRC64;
MDKIKKFFSS LNTSQEKIVF SKSKNPMLVL AGPGSGKTRV IIAKIVYLIK YMNIDPNEIL
ALTFTNKAAN EMNDRINDLL KFDKKLHIQT FHSFGSWLLR VYYKDFNENY DSNFTIWDTN
DVVKFVKQID LAPNLEMAKH IAALILKDKE NFFLEKFIQF TEKEYEYIKI YEEEKAKNNA
FDFSDLIIKP ILMLRQSKSL KESIQSRFKV IFVDEYQDTN YSQFLFLKEL YLDGMYFMVV
GDEDQSIYSF RGARIENILE FEKTFDNVIK FYLVQNYRSN SNIVGIANEV ISKNKNRYEK
QITTQNSSNK RMKFLVFQST SDEAEYFSNL LISNDIKTAI LYRFNSQSFH FETSFLKKNI
PYKVLGSIKF YDREEIKDII CLLRLFINKK DKISFLRMIN KPSRGIGKTT LDKIISSLND
KDVNFNLFCA SKKTLGLLKN RAKESLLLFL NVYEELGKKL FEDNYINLSA FIEDVVIRFG
LLDYYRKFDK DEKLRNIDEL INSGIEYSGT FEGLAIFLEN SSLSPLISGD FKSNILLSSI
HGVKGLEFDR VVISGLEKGL LPAEIEELTE DRLEEERRLF YVAITRAKSE LIVTLNLRRA
FRGSYKGTLP SVFFQDIDKN SYDIIFIPEY LKENFNNFFI NNKRDIGFNI GDYIIYNGEK
GIVVDSWYQS NLQFVKISLR NGKKAILSPE YIKKIVKV
//