ID O51626_BORBU Unreviewed; 407 AA.
AC O51626;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 08-NOV-2023, entry version 119.
DE SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:AAC67034.1};
DE EC=2.3.3.10 {ECO:0000313|EMBL:AAC67034.1};
GN OrderedLocusNames=BB_0683 {ECO:0000313|EMBL:AAC67034.1};
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borreliella.
OX NCBI_TaxID=224326 {ECO:0000313|EMBL:AAC67034.1, ECO:0000313|Proteomes:UP000001807};
RN [1] {ECO:0000313|EMBL:AAC67034.1, ECO:0000313|Proteomes:UP000001807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680
RC {ECO:0000313|Proteomes:UP000001807};
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R., Lathigra R.,
RA White O., Ketchum K.A., Dodson R., Hickey E.K., Gwinn M., Dougherty B.,
RA Tomb J.F., Fleischmann R.D., Richardson D., Peterson J., Kerlavage A.R.,
RA Quackenbush J., Salzberg S., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J., Weidman J., Utterback T., Watthey L., McDonald L., Artiach P.,
RA Bowman C., Garland S., Fuji C., Cotton M.D., Horst K., Roberts K.,
RA Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC family. {ECO:0000256|ARBA:ARBA00007061}.
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DR EMBL; AE000783; AAC67034.1; -; Genomic_DNA.
DR PIR; B70185; B70185.
DR RefSeq; NP_212817.1; NC_001318.1.
DR RefSeq; WP_010889798.1; NC_001318.1.
DR AlphaFoldDB; O51626; -.
DR STRING; 224326.BB_0683; -.
DR PaxDb; 224326-BB_0683; -.
DR EnsemblBacteria; AAC67034; AAC67034; BB_0683.
DR KEGG; bbu:BB_0683; -.
DR PATRIC; fig|224326.49.peg.1074; -.
DR HOGENOM; CLU_008065_3_0_12; -.
DR OMA; DDAYNWI; -.
DR OrthoDB; 9769523at2; -.
DR BRENDA; 2.3.3.10; 902.
DR Proteomes; UP000001807; Chromosome.
DR GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR InterPro; IPR013528; HMG_CoA_synth_N.
DR InterPro; IPR011554; HMG_CoA_synthase_prok.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01835; HMG-CoA-S_prok; 1.
DR PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR43323:SF2; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR Pfam; PF08540; HMG_CoA_synt_C; 1.
DR Pfam; PF01154; HMG_CoA_synt_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AAC67034.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001807};
KW Transferase {ECO:0000313|EMBL:AAC67034.1}.
FT DOMAIN 3..180
FT /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01154"
FT DOMAIN 295..379
FT /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08540"
FT ACT_SITE 89
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR611554-1"
FT ACT_SITE 126
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR611554-1"
FT ACT_SITE 253
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR611554-1"
FT BINDING 159
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR611554-2"
FT BINDING 300
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR611554-2"
SQ SEQUENCE 407 AA; 46029 MW; 71ED5F0C0BB5D860 CRC64;
MRIGISDIRI FLPLNYLDFS VLLENPLYFS NEVFFKKINR AIDATLQKGF RFTSPNEDSV
TMASSAVKLI FDNNNLDLSK IRILLGGTET GVDHSKAISS YVFGALKQSG ICLGNNFLTF
QVQHACAGAA MSLHTVASVL SHSNNSEYGI VFSSDIAHYS NLTTAEITQG AGATAILIEK
NPKLLSINLS EFGVYTDDVD DFFRPFGSVE AKVRGQYSVE CYNNANENAL RDFAFKKQLS
MKDLFSNYRF VLHVPFAKMP IDSMHYILKK YYSDDESVRN AYLESIDFYD GVEAAMEVGN
LYTGSIFLSL AFYLKRVFSK KDITGEKILF CSYGSGNIMI IYELTIEKSA FDVIKLWDLE
GLIKNRNNAN FEEYKDFFQN KIIPGESRGF YLKELRNDGY RVYGYRA
//