ID O53463_MYCTU Unreviewed; 346 AA.
AC O53463; I6Y853; L0TB93;
DT 01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JUN-1998, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=Transcriptional regulatory protein {ECO:0000313|EMBL:CCP44789.1};
GN OrderedLocusNames=Rv2017 {ECO:0000313|EMBL:CCP44789.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP44789.1, ECO:0000313|Proteomes:UP000001584};
RN [1] {ECO:0000313|EMBL:CCP44789.1, ECO:0000313|Proteomes:UP000001584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2] {ECO:0007829|PubMed:21969609}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SIMILARITY: Belongs to the short-chain fatty acyl-CoA assimilation
CC regulator (ScfR) family. {ECO:0000256|ARBA:ARBA00007227}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP44789.1; -; Genomic_DNA.
DR RefSeq; NP_216533.1; NC_000962.3.
DR RefSeq; WP_003911735.1; NZ_NVQJ01000046.1.
DR AlphaFoldDB; O53463; -.
DR SMR; O53463; -.
DR STRING; 83332.Rv2017; -.
DR PaxDb; 83332-Rv2017; -.
DR DNASU; 888435; -.
DR GeneID; 888435; -.
DR KEGG; mtu:Rv2017; -.
DR PATRIC; fig|83332.111.peg.2248; -.
DR eggNOG; COG1396; Bacteria.
DR eggNOG; COG2856; Bacteria.
DR InParanoid; O53463; -.
DR OrthoDB; 9794834at2; -.
DR PhylomeDB; O53463; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.10.2910; -; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010359; IrrE_HExxH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR43236; ANTITOXIN HIGA1; 1.
DR PANTHER; PTHR43236:SF1; BLL7220 PROTEIN; 1.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF06114; Peptidase_M78; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT DOMAIN 8..61
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
SQ SEQUENCE 346 AA; 38605 MW; 1C4286EE1444DC95 CRC64;
MNGLGDVLAV ARKARGLTQI ELAELVGLTQ PAINRYESGD RDPDQHIVAK LAEILGVTDD
LLIHGNRFRG ALAVDAHMRR HKTTKASAWR QLEARLNLLR VHASFLFEEV AINSEQHVPA
FDPEFTAAED AARLVRAQWR MPMGPVVNLT RWMEAAGCLV FEEDFATQRI DGLSQWVDDY
PVMLINANAA PDRKRLTLAH ELGHLVLHST NPTENMETEA TAFAAEFLMP ESEIRPELRR
LDLGKLLELK REWGVSMQAL LARAYRMGLV SAEARTKLYK AMNARGWKTK EPGIESIVRE
KPSLPAHIGM TLRSRGFTDQ QAAAIAGYAN PADNPFRPEG GRLHAI
//
