ID O58871_PYRHO Unreviewed; 148 AA.
AC O58871;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=HTH dtxR-type domain-containing protein {ECO:0000259|PROSITE:PS50944};
GN OrderedLocusNames=PH1163 {ECO:0000313|EMBL:BAA30263.1};
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601 {ECO:0000313|EMBL:BAA30263.1, ECO:0000313|Proteomes:UP000000752};
RN [1] {ECO:0000313|EMBL:BAA30263.1, ECO:0000313|Proteomes:UP000000752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3
RC {ECO:0000313|Proteomes:UP000000752};
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Nakamura Y.,
RA Robb T.F., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
CC -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC {ECO:0000256|ARBA:ARBA00007871}.
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DR EMBL; BA000001; BAA30263.1; -; Genomic_DNA.
DR PIR; E71058; E71058.
DR RefSeq; WP_010885248.1; NC_000961.1.
DR AlphaFoldDB; O58871; -.
DR STRING; 70601.gene:9378124; -.
DR EnsemblBacteria; BAA30263; BAA30263; BAA30263.
DR GeneID; 1443483; -.
DR KEGG; pho:PH1163; -.
DR eggNOG; arCOG02100; Archaea.
DR OrthoDB; 24735at2157; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR PANTHER; PTHR33238:SF7; TRANSCRIPTIONAL REGULATOR MNTR; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..63
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50944"
SQ SEQUENCE 148 AA; 17401 MW; F9FC110F18215356 CRC64;
MVSKREEEYL EVMYLLQKNK GVIRVKDIAK ILKVKPPSVV DALKKLSKKG LVEYEKHDRI
TLTEEGRKIA EETYSKHILL TEFFTNVLGI PPEIAEEDAC QFEHYVSEVT VKRIREFITY
IQENCPYVLK QFLKKVQEED KNQKTPAR
//