ID ONEC3_HUMAN Reviewed; 494 AA.
AC O60422; A8MZM7;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 24-JAN-2024, entry version 161.
DE RecName: Full=One cut domain family member 3;
DE AltName: Full=One cut homeobox 3;
DE AltName: Full=Transcription factor ONECUT-3;
DE Short=OC-3;
GN Name=ONECUT3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=11944891; DOI=10.1006/bbrc.2002.6760;
RA Vanhorenbeeck V., Jacquemin P., Lemaigre F.P., Rousseau G.G.;
RT "OC-3, a novel mammalian member of the ONECUT class of transcription
RT factors.";
RL Biochem. Biophys. Res. Commun. 292:848-854(2002).
CC -!- FUNCTION: Transcriptional activator. Binds the consensus DNA sequence
CC 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of
CC HNF3B and TTR (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O60422; Q99828: CIB1; NbExp=3; IntAct=EBI-17431136, EBI-372594;
CC O60422; O43639: NCK2; NbExp=3; IntAct=EBI-17431136, EBI-713635;
CC O60422; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-17431136, EBI-12030590;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00374}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family. {ECO:0000305}.
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DR EMBL; AC004755; AAC17602.1; -; Genomic_DNA.
DR EMBL; AC005256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45900.1; -.
DR RefSeq; NP_001073957.1; NM_001080488.1.
DR AlphaFoldDB; O60422; -.
DR SMR; O60422; -.
DR BioGRID; 133716; 4.
DR IntAct; O60422; 3.
DR STRING; 9606.ENSP00000371786; -.
DR iPTMnet; O60422; -.
DR PhosphoSitePlus; O60422; -.
DR BioMuta; ONECUT3; -.
DR EPD; O60422; -.
DR MassIVE; O60422; -.
DR PaxDb; 9606-ENSP00000371786; -.
DR PeptideAtlas; O60422; -.
DR ProteomicsDB; 49395; -.
DR Antibodypedia; 5527; 167 antibodies from 20 providers.
DR DNASU; 390874; -.
DR Ensembl; ENST00000382349.5; ENSP00000371786.4; ENSG00000205922.5.
DR GeneID; 390874; -.
DR KEGG; hsa:390874; -.
DR MANE-Select; ENST00000382349.5; ENSP00000371786.4; NM_001080488.2; NP_001073957.1.
DR UCSC; uc010xgr.3; human.
DR AGR; HGNC:13399; -.
DR CTD; 390874; -.
DR GeneCards; ONECUT3; -.
DR HGNC; HGNC:13399; ONECUT3.
DR HPA; ENSG00000205922; Tissue enhanced (retina, stomach).
DR MIM; 611294; gene.
DR neXtProt; NX_O60422; -.
DR OpenTargets; ENSG00000205922; -.
DR PharmGKB; PA31926; -.
DR VEuPathDB; HostDB:ENSG00000205922; -.
DR eggNOG; KOG2252; Eukaryota.
DR GeneTree; ENSGT00950000183103; -.
DR HOGENOM; CLU_018642_0_0_1; -.
DR InParanoid; O60422; -.
DR OMA; WHDDHGA; -.
DR OrthoDB; 5396912at2759; -.
DR PhylomeDB; O60422; -.
DR TreeFam; TF318206; -.
DR PathwayCommons; O60422; -.
DR Reactome; R-HSA-210744; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
DR Reactome; R-HSA-210747; Regulation of gene expression in early pancreatic precursor cells.
DR SignaLink; O60422; -.
DR BioGRID-ORCS; 390874; 17 hits in 1170 CRISPR screens.
DR GenomeRNAi; 390874; -.
DR Pharos; O60422; Tbio.
DR PRO; PR:O60422; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O60422; Protein.
DR Bgee; ENSG00000205922; Expressed in buccal mucosa cell and 17 other cell types or tissues.
DR Genevisible; O60422; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14057:SF34; ONE CUT DOMAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR14057; TRANSCRIPTION FACTOR ONECUT; 1.
DR Pfam; PF02376; CUT; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS51042; CUT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..494
FT /note="One cut domain family member 3"
FT /id="PRO_0000271218"
FT DNA_BIND 312..398
FT /note="CUT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00374"
FT DNA_BIND 414..473
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 130..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 50037 MW; FB97DF2CBA336B82 CRC64;
MELSLESLGG LHSVAHAQAG ELLSPGHARS AAAQHRGLVA PGRPGLVAGM ASLLDGGGGG
GGGGAGGAGG AGSAGGGADF RGELAGPLHP AMGMACEAPG LGGTYTTLTP LQHLPPLAAV
ADKFHQHAAA AAVAGAHGGH PHAHPHPAAA PPPPPPPQRL AASVSGSFTL MRDERAALAS
VGHLYGPYGK ELPAMGSPLS PLPNALPPAL HGAPQPPPPP PPPPLAAYGP PGHLAGDKLL
PPAAFEPHAA LLGRAEDALA RGLPGGGGGT GSGGAGSGSA AGLLAPLGGL AAAGAHGPHG
GGGGPGGSGG GPSAGAAAEE INTKEVAQRI TAELKRYSIP QAIFAQRILC RSQGTLSDLL
RNPKPWSKLK SGRETFRRMW KWLQEPEFQR MSALRLAACK RKEQEQQKER ALQPKKQRLV
FTDLQRRTLI AIFKENKRPS KEMQVTISQQ LGLELNTVSN FFMNARRRCM NRWAEEPSTA
PGGPAGATAT FSKA
//
