ID O64877_ARATH Unreviewed; 646 AA.
AC O64877;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 27-MAR-2024, entry version 182.
DE SubName: Full=At2g44430 {ECO:0000313|EMBL:AAP78932.1};
DE SubName: Full=DNA-binding bromodomain-containing protein {ECO:0000313|EMBL:AEC10419.1};
GN OrderedLocusNames=At2g44430 {ECO:0000313|Araport:AT2G44430,
GN ECO:0000313|EMBL:AAM53265.1};
GN ORFNames=F4I1.24 {ECO:0000313|EMBL:AEC10419.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AAC16089.1};
RN [1] {ECO:0000313|EMBL:AEC10419.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S., Shea T.P., Benito M.I., Town C.D.,
RA Fujii C.Y., Mason T., Bowman C.L., Barnstead M., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2] {ECO:0000313|EMBL:AAC16089.1}
RP NUCLEOTIDE SEQUENCE.
RA Rounsley S.D., Lin X., Ketchum K.A., Crosby M.L., Brandon R.C., Sykes S.M.,
RA Kaul S., Mason T.M., Kerlavage A.R., Adams M.D., Somerville C.R.,
RA Venter J.C.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAC16089.1}
RP NUCLEOTIDE SEQUENCE.
RA Town C.D., Kaul S.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAM53265.1}
RP NUCLEOTIDE SEQUENCE.
RA Southwick A., Karlin-Neumann G., Nguyen M., Tripp M., Miranda M.,
RA Palm C.J., Bowser L., Jones T., Banh J., Carninci P., Chen H., Cheuk R.,
RA Chung M.K., Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Kim C., Lin J.,
RA Liu S.X., Narusaka M., Pham P.K., Sakano H., Sakurai T., Satou M., Seki M.,
RA Shinn P., Yamada K., Shinozaki K., Ecker J., Theologis A., Davis R.W.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAP78932.1}
RP NUCLEOTIDE SEQUENCE.
RA Cheuk R., Chen H., Kim C.J., Shinn P., Bowser L., Carninci P., Dale J.M.,
RA Hayashizaki Y., Ishida J., Jones T., Kamiya A., Karlin-Neumann G.,
RA Kawai J., Lam B., Lin J., Miranda M., Narusaka M., Nguyen M., Onodera C.S.,
RA Palm C.J., Quach H.L., Sakurai T., Satou M., Seki M., Southwick A.,
RA Toriumi M., Wong C., Wu H.C., Yamada K., Yu G., Shinozaki K., Davis R.W.,
RA Theologis A., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AEC10419.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AEC10419.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
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DR EMBL; AC004521; AAC16089.1; -; Genomic_DNA.
DR EMBL; AY120707; AAM53265.1; -; mRNA.
DR EMBL; BT009664; AAP78932.1; -; mRNA.
DR EMBL; CP002685; AEC10419.1; -; Genomic_DNA.
DR PIR; T02398; T02398.
DR RefSeq; NP_181971.1; NM_130006.3.
DR AlphaFoldDB; O64877; -.
DR SMR; O64877; -.
DR STRING; 3702.O64877; -.
DR PaxDb; 3702-AT2G44430-1; -.
DR ProteomicsDB; 185311; -.
DR EnsemblPlants; AT2G44430.1; AT2G44430.1; AT2G44430.
DR GeneID; 819050; -.
DR Gramene; AT2G44430.1; AT2G44430.1; AT2G44430.
DR KEGG; ath:AT2G44430; -.
DR Araport; AT2G44430; -.
DR TAIR; AT2G44430; -.
DR eggNOG; ENOG502QR9N; Eukaryota.
DR HOGENOM; CLU_017796_1_0_1; -.
DR OMA; HCEQKFH; -.
DR OrthoDB; 472859at2759; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O64877; baseline and differential.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd04369; Bromodomain; 1.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR37888; DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37888:SF11; MYB-RELATED TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 1: Evidence at protein level;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW DNA-binding {ECO:0000313|EMBL:AEC10419.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:O64877,
KW ECO:0007829|ProteomicsDB:O64877};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 42..101
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 320..383
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 72405 MW; 104D7EB0E7E2AD42 CRC64;
MRKEEEEEAG SYNMNVDDTN NNNNYICTDN DYIEEDEDNS NTKKSQTQAW GTWEELLLAC
AVKRHGFGDW DSVATEVRSR SSLSHLLASA NDCRHKYRDL KRRFHEQEKT DVTATVEEEE
EEEERVGNNI PWLEQLRNLR VAELRREVER YDCSILSLQL KVKKLEEERE VGEEKPDLEN
ERKEERSEND GSESEHREKA VSAAEESDRE NRSMNESNST ATAGEEERVC GDEPSQTRED
DSGNDKNPDP DPVNKDATAA EEEEGSVSRG SEASHSDELG ESGTSESKWK RKRRKQGGAG
EIRSAESKSQ PLISLLDLIR SHPRGSLFER RLRSQEAKDY KSMVKQHLDI ETIQRKLKQG
SYDSSSLIFY RDLQLLFTNA IVFFPLSSSE SMAAHELRAV VSQEMRKETG KAGPRLIKQE
ASGMRSGKAD AETSDSSLSR QKSSGPLVVC KKRRSVSAKA SPSSSSFSQK DDTKEETLSE
EKDNIATGVR SSRRANKVAA VVANNTKTGK GRNKQKQTES KTNSSNDNSS KQDTGKTEKK
TVSADKKKSV ADFLKRLKKN SPQKEAKDQN KSGGNVKKDS KTKPRELRSS SVGKKKAEVE
NTPVKRAPGR PQKKTAEATA SASGKRGRDT GSTGKDNKQP KKRIRK
//
