ID O66925_AQUAE Unreviewed; 660 AA.
AC O66925;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=N-methylhydantoinase A {ECO:0000313|EMBL:AAC06888.1};
GN Name=hyuA {ECO:0000313|EMBL:AAC06888.1};
GN OrderedLocusNames=aq_708 {ECO:0000313|EMBL:AAC06888.1};
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC06888.1, ECO:0000313|Proteomes:UP000000798};
RN [1] {ECO:0000313|EMBL:AAC06888.1, ECO:0000313|Proteomes:UP000000798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5 {ECO:0000313|EMBL:AAC06888.1,
RC ECO:0000313|Proteomes:UP000000798};
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
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DR EMBL; AE000657; AAC06888.1; -; Genomic_DNA.
DR PIR; A70362; A70362.
DR RefSeq; NP_213485.1; NC_000918.1.
DR RefSeq; WP_010880423.1; NC_000918.1.
DR AlphaFoldDB; O66925; -.
DR STRING; 224324.aq_708; -.
DR EnsemblBacteria; AAC06888; AAC06888; aq_708.
DR KEGG; aae:aq_708; -.
DR PATRIC; fig|224324.8.peg.567; -.
DR eggNOG; COG0145; Bacteria.
DR HOGENOM; CLU_002157_1_2_0; -.
DR InParanoid; O66925; -.
DR OrthoDB; 9768323at2; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR InterPro; IPR049517; ACX-like_C.
DR InterPro; IPR008040; Hydant_A_N.
DR InterPro; IPR002821; Hydantoinase_A.
DR InterPro; IPR045079; Oxoprolinase_fam.
DR PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR PANTHER; PTHR11365:SF23; HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF19278; Hydant_A_C; 1.
DR Pfam; PF05378; Hydant_A_N; 1.
DR Pfam; PF01968; Hydantoinase_A; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000798}.
FT DOMAIN 5..174
FT /note="Hydantoinase/oxoprolinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05378"
FT DOMAIN 194..476
FT /note="Hydantoinase A/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF01968"
FT DOMAIN 486..652
FT /note="Acetophenone carboxylase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19278"
SQ SEQUENCE 660 AA; 73393 MW; 08C69AC52977D821 CRC64;
MRVYVGVDTG GTFTDFVYWD GKEWRVLKIP STPSNPAEAV LKGLEKLRRG KALDVVHGST
VATNALLERK GAKTALITNK GFEDVIEIGR QNRERLYDLY YRKPKPLVPR ELRFGLNCRI
NAKGEVLKPI NREELKEILK ALKEKGVESV AVCMLHSYAN PEHEKEVEEE LKKNLSVFVS
LSSEILPEFR EYERCSTTVI NAYVSPKMSK YLYYLKDRLR EGDLFRVMQS NGGLISPETA
SKEAVRTILS GPAGGVIGAL HLGKLAGFEK LITFDMGGTS TDVSLIYGTP NITTESKIDG
LPVKVPMIDI NTVGAGGGSI AYVDEGGALR VGPQSAGAQP GPICYGRGGK EITVTDANLF
LGRLVPEHFL GGEMKLYPEL LEEPFKEMAK KIGLAPTELA EGIIKVANSS MERAIRKVSV
ERGYNPEEFA LFSFGGAGGL HAVLLAKSLN IPKVIIPRNP GLLSAVGMLF ADIVKDKVTT
VMLKEEEAKP ETLEKLFLLM EEKVLSEMEG EGFPPEKVFV ERFLDVRYKG QSYEITIPFG
ENFKETFEKE HERLYGYAHR GRKIEIVNLR IKATGIKEKP PLKEFKERGD KYPKDAILGE
REVVFEGRLE TFKVLDREKL VYGNVIDFPA IVVEYSSTTL IPPYATAEVD RYGNLIITLL
//
