ID O67268_AQUAE Unreviewed; 236 AA.
AC O67268;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 27-MAR-2024, entry version 153.
DE SubName: Full=RNA polymerase sigma factor FliA {ECO:0000313|EMBL:AAC07229.1};
GN Name=fliA {ECO:0000313|EMBL:AAC07229.1};
GN OrderedLocusNames=aq_1218 {ECO:0000313|EMBL:AAC07229.1};
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC07229.1, ECO:0000313|Proteomes:UP000000798};
RN [1] {ECO:0000313|EMBL:AAC07229.1, ECO:0000313|Proteomes:UP000000798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5 {ECO:0000313|EMBL:AAC07229.1,
RC ECO:0000313|Proteomes:UP000000798};
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
RN [2] {ECO:0007829|PDB:1RP3, ECO:0007829|PDB:1SC5}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
RX PubMed=15068809; DOI=10.1016/S1097-2765(04)00150-9;
RA Sorenson M.K., Ray S.S., Darst S.A.;
RT "Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM
RT reveals an intact sigma factor in an inactive conformation.";
RL Mol. Cell 14:127-138(2004).
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DR EMBL; AE000657; AAC07229.1; -; Genomic_DNA.
DR PIR; A70405; A70405.
DR RefSeq; NP_213832.1; NC_000918.1.
DR RefSeq; WP_010880770.1; NC_000918.1.
DR PDB; 1RP3; X-ray; 2.30 A; A/C/E/G=1-236.
DR PDB; 1SC5; X-ray; 3.26 A; A=1-236.
DR PDBsum; 1RP3; -.
DR PDBsum; 1SC5; -.
DR AlphaFoldDB; O67268; -.
DR SMR; O67268; -.
DR IntAct; O67268; 1.
DR STRING; 224324.aq_1218; -.
DR EnsemblBacteria; AAC07229; AAC07229; aq_1218.
DR KEGG; aae:aq_1218; -.
DR PATRIC; fig|224324.8.peg.946; -.
DR eggNOG; COG1191; Bacteria.
DR HOGENOM; CLU_014793_8_1_0; -.
DR InParanoid; O67268; -.
DR OrthoDB; 9799825at2; -.
DR EvolutionaryTrace; O67268; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:1903865; C:sigma factor antagonist complex; IDA:CAFA.
DR GO; GO:0045152; F:antisigma factor binding; IDA:CAFA.
DR GO; GO:0097718; F:disordered domain specific binding; IPI:CAFA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd06171; Sigma70_r4; 1.
DR Gene3D; 1.10.1740.10; -; 1.
DR Gene3D; 1.20.140.160; -; 1.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR000943; RNA_pol_sigma70.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR007624; RNA_pol_sigma70_r3.
DR InterPro; IPR007630; RNA_pol_sigma70_r4.
DR InterPro; IPR012845; RNA_pol_sigma_FliA_WhiG.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR NCBIfam; TIGR02479; FliA_WhiG; 1.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR PANTHER; PTHR30385:SF7; RNA POLYMERASE SIGMA FACTOR FLIA; 1.
DR PANTHER; PTHR30385; SIGMA FACTOR F FLAGELLAR; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF04539; Sigma70_r3; 1.
DR Pfam; PF04545; Sigma70_r4; 1.
DR PIRSF; PIRSF000770; RNA_pol_sigma-SigE/K; 1.
DR PRINTS; PR00046; SIGMA70FCT.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 2.
DR PROSITE; PS00715; SIGMA70_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:1RP3, ECO:0007829|PDB:1SC5};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000000798};
KW Sigma factor {ECO:0000256|ARBA:ARBA00023082};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 41..54
FT /note="RNA polymerase sigma-70"
FT /evidence="ECO:0000259|PROSITE:PS00715"
SQ SEQUENCE 236 AA; 27409 MW; AB8025759809C9A6 CRC64;
MKNPYSNQIE REELILKYLP LVKAIATNIK KHLPEDVDIR DLISYGVIGL IKAVDNLSTE
NPKRAEAYIK LRIKGAIYDY LRSLDFGSRQ VREKERRIKE VVEKLKEKLG REPTDEEVAK
ELGISTEELF KTLDKINFSY ILSLEEVFRD FARDYSELIP SSTNVEEEVI KRELTEKVKE
AVSKLPEREK LVIQLIFYEE LPAKEVAKIL ETSVSRVSQL KAKALERLRE MLSNPL
//
