ID O67325_AQUAE Unreviewed; 810 AA.
AC O67325;
DT 01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT 01-AUG-1998, sequence version 1.
DT 28-JUN-2023, entry version 134.
DE SubName: Full=ATP-dependent Clp protease {ECO:0000313|EMBL:AAC07290.1};
GN Name=clpC {ECO:0000313|EMBL:AAC07290.1};
GN OrderedLocusNames=aq_1296 {ECO:0000313|EMBL:AAC07290.1};
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC07290.1, ECO:0000313|Proteomes:UP000000798};
RN [1] {ECO:0000313|EMBL:AAC07290.1, ECO:0000313|Proteomes:UP000000798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5 {ECO:0000313|EMBL:AAC07290.1,
RC ECO:0000313|Proteomes:UP000000798};
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; AE000657; AAC07290.1; -; Genomic_DNA.
DR PIR; B70412; B70412.
DR RefSeq; NP_213889.1; NC_000918.1.
DR RefSeq; WP_010880827.1; NC_000918.1.
DR AlphaFoldDB; O67325; -.
DR STRING; 224324.aq_1296; -.
DR EnsemblBacteria; AAC07290; AAC07290; aq_1296.
DR KEGG; aae:aq_1296; -.
DR PATRIC; fig|224324.8.peg.1013; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_1_0; -.
DR InParanoid; O67325; -.
DR OMA; ERMKAVM; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:AAC07290.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:AAC07290.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000798};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 2..141
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 410..445
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT COILED 406..433
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 810 AA; 92356 MW; 5DC9A95904AA38E7 CRC64;
MFEKFTERAR QVILRAREEA LELGHSYLGS EHILLALIKD EDIPVLVLSK LGVSPEKIRK
AIMGQITKGS HSGEVLFAPD AKRVIEFAVE EARILHHQFV GPEHLLIGVV REKTGLGGRI
LRSFGLDEYS VRREVLQLLG ELPPQESQRY VSTPNLDRFS RDLTQMAREG KLDPVIGREK
EIERVIQILV RRRKNNPVLL GDPGVGKTAI VEGLAQRIAN KEVPEPLLNK RVVALDLAAL
VAGTKYRGQF EERLKNILKE LEKANNVILF IDELHTLVGA GSAEGSIDAS NMLKPALARG
EIQVIGATTV DEYRKYIEKD GALERRFQPV YVEQPSPEDT IQILYGLKPK FEEFHKVEYT
PEAIEKAVEL SVKYITDRNL PDKAIDVMDE AGALVKLKAT QLPPELKEIE EKIKELEKEK
EKAVKEQDYE KAAKIRDEEL RLRAKFETMK AKWKEEMEKN RPKVTDEDVA EVVARWTGVP
VKRVHESDAE KLLHIEEELK KRVVGQDEAI KAVAKAIRRS RVGLKGKHRP IGVFMFLGPT
GVGKTETAKA LAEYLFGTED ALIRFDMSEY MEKHTVSRLI GAPPGYVGYE EGGQLTEAVR
RRPYSVLLFD EIEKAHPDVF NIFLQIFDDG RLTDGLGRTV DFSNTIIIMT SNLGARLITG
GTMGFEKKQG LLNFEEMRKN VLDQVKRTFS PEFLNRLDEI IVFRPLEKKD IEQILELQLK
EINEKLKDWN VRVKLHKSFV NWIIEKEYKP EFGARSLKRA LQRHVEDLLA EELIKGTLKG
VEEVEIRVRN DKPYLKPVKK KEKVEALLEK
//