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Database: UniProt
Entry: O74405
LinkDB: O74405
Original site: O74405 
ID   SET11_SCHPO             Reviewed;         381 AA.
AC   O74405;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JAN-2019, entry version 111.
DE   RecName: Full=Ribosomal lysine N-methyltransferase set11;
DE            EC=2.1.1.-;
DE   AltName: Full=Meiotically up-regulated gene 76 protein;
DE   AltName: Full=SET domain-containing protein 11;
GN   Name=set11; Synonyms=mug76; ORFNames=SPCC1223.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L.,
RA   San-Segundo P., Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes
RT   required for critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF 189-ASN--PRO-192
RP   AND 216-GLY--TYR-224.
RX   PubMed=18195021; DOI=10.1074/jbc.M709429200;
RA   Sadaie M., Shinmyozu K., Nakayama J.;
RT   "A conserved SET domain methyltransferase, Set11, modifies ribosomal
RT   protein Rpl12 in fission yeast.";
RL   J. Biol. Chem. 283:7185-7195(2008).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that trimethylates 60S ribosomal protein L12
CC       (rpl1201 and rpl1202) at 'Lys-4' and may dimethylate L12 also at
CC       'Lys-40' and 'Lys-41'. Overexpression causes a severe growth
CC       defect. Has a role in meiosis. {ECO:0000269|PubMed:16303567,
CC       ECO:0000269|PubMed:18195021}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. RKM2 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190, ECO:0000305}.
DR   EMBL; CU329672; CAA20873.1; -; Genomic_DNA.
DR   PIR; T40864; T40864.
DR   RefSeq; NP_588349.1; NM_001023340.1.
DR   ProteinModelPortal; O74405; -.
DR   BioGrid; 275802; 37.
DR   STRING; 4896.SPCC1223.04c.1; -.
DR   PaxDb; O74405; -.
DR   PRIDE; O74405; -.
DR   EnsemblFungi; SPCC1223.04c.1; SPCC1223.04c.1:pep; SPCC1223.04c.
DR   GeneID; 2539232; -.
DR   KEGG; spo:SPCC1223.04c; -.
DR   EuPathDB; FungiDB:SPCC1223.04c; -.
DR   PomBase; SPCC1223.04c; set11.
DR   InParanoid; O74405; -.
DR   OMA; NTRCLYY; -.
DR   PhylomeDB; O74405; -.
DR   PRO; PR:O74405; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005730; C:nucleolus; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IDA:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0018022; P:peptidyl-lysine methylation; IDA:PomBase.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   GO; GO:0018023; P:peptidyl-lysine trimethylation; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; TAS:PomBase.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR016852; SET_MeTrfase.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF027158; Lys_MTase_YDR198C_prd; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Meiosis; Methyltransferase; Nucleus;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    381       Ribosomal lysine N-methyltransferase
FT                                set11.
FT                                /FTId=PRO_0000116804.
FT   DOMAIN       23    224       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   BINDING     223    223       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190}.
FT   MUTAGEN     189    192       Missing: Abolishes enzymatic activity.
FT                                {ECO:0000269|PubMed:18195021}.
FT   MUTAGEN     216    224       Missing: Abolishes enzymatic activity.
FT                                {ECO:0000269|PubMed:18195021}.
SQ   SEQUENCE   381 AA;  44080 MW;  3EE7D5A3DD364169 CRC64;
     MSNKQNIESE VSWVKSKGAF VHPSLEFSVI PDAGSCVLAN NDINENTVLL KLPPNILINK
     RTCSRYSFRD KLTSFQFLSW LISEDVHSNL EISPYYTKAL PQGFSFHPVT LTSDHPLWSI
     LPDEVRNSLL ERKNVMAFDY EQVKKFVSVD QPTFQWGWLC VNTRCLYYDT GSKNTEDHLT
     LAPIFEYFNH SPEAQTALIN TRGTITIKST RRIDKGEQIF LCYGPHGNDK LFTEYGFCLS
     NNPNISIQLD RFIEFDKWQQ SFLQDHGYWN DYTCSLHGAS FRTLVGVRTL LVSPSEKLND
     ASYDQTRRVL QYINGFSDGS RDRQDVEDYL KKVLQELLCE AEECKEKVKG ISDGSYVFIC
     AEQLWKDRIM CCQYLMEHSF E
//
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