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Database: UniProt
Entry: O74738
LinkDB: O74738
Original site: O74738 
ID   SET10_SCHPO             Reviewed;         547 AA.
AC   O74738;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JAN-2019, entry version 87.
DE   RecName: Full=Ribosomal lysine N-methyltransferase set10;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 10;
GN   Name=set10; ORFNames=SPBC1709.13c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=18292091; DOI=10.1074/jbc.M709211200;
RA   Shirai A., Matsuyama A., Yashiroda Y., Hashimoto A., Kawamura Y.,
RA   Arai R., Komatsu Y., Horinouchi S., Yoshida M.;
RT   "Global analysis of gel mobility of proteins and its use in target
RT   identification.";
RL   J. Biol. Chem. 283:10745-10752(2008).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that methylates ribosomal protein L23 (rpl23a
CC       and rpl23b). {ECO:0000269|PubMed:18292091}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. RKM1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190, ECO:0000305}.
DR   EMBL; CU329671; CAA21252.1; -; Genomic_DNA.
DR   PIR; T39641; T39641.
DR   RefSeq; NP_595446.1; NM_001021355.2.
DR   ProteinModelPortal; O74738; -.
DR   SMR; O74738; -.
DR   BioGrid; 276370; 19.
DR   STRING; 4896.SPBC1709.13c.1; -.
DR   MaxQB; O74738; -.
DR   PaxDb; O74738; -.
DR   PRIDE; O74738; -.
DR   EnsemblFungi; SPBC1709.13c.1; SPBC1709.13c.1:pep; SPBC1709.13c.
DR   GeneID; 2539820; -.
DR   KEGG; spo:SPBC1709.13c; -.
DR   EuPathDB; FungiDB:SPBC1709.13c; -.
DR   PomBase; SPBC1709.13c; set10.
DR   InParanoid; O74738; -.
DR   OMA; PFEYAIT; -.
DR   PhylomeDB; O74738; -.
DR   PRO; PR:O74738; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IMP:PomBase.
DR   GO; GO:0018027; P:peptidyl-lysine dimethylation; ISO:PomBase.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; NAS:PomBase.
DR   InterPro; IPR011219; Rubisco-cyt_methylase_MET.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF026986; MET_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase; Nucleus;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    547       Ribosomal lysine N-methyltransferase
FT                                set10.
FT                                /FTId=PRO_0000303949.
FT   DOMAIN       17    235       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   BINDING     234    234       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190}.
SQ   SEQUENCE   547 AA;  62320 MW;  03F965BB7B70271A CRC64;
     MEKLLHEALQ NGCKLHKSVE FIQSRDDNAC FGSYIAVAQN DIAPDQLLIS CPFEYAITYN
     KAKEELKKLN PNFESCNPHI TLCTFLALES LKGIQSKWYG YIEYLPKTFN TPLYFNENDN
     AFLISTNAYS AAQERLHIWK HEYQEALSLH PSPTERFTFD LYIWSATVFS SRCFSSNLIY
     KDSESTPILL PLIDSLNHKP KQPILWNSDF QDEKSVQLIS QELVAKGNQL FNNYGPKGNE
     ELLMGYGFCL PDNPFDTVTL KVAIHPDLPH KDQKAAILEN DCQFQLSNLV FFLPKSPDKE
     IFQKILQCLA VVTASSLELR KLTAHLLTGD LASYVPSLRG QIKSLEVLLM YIDSRADLLL
     KSNPQVSPTS ERQVWAKIYR DSQINILQDS ITYVKNYMEE SLQKTYKPLP NLLQYLILNS
     ISIFLLQHPL FAPLSHAIES LYGSTDAEAL VATDEQDILM ILICVYCLSI SEKLPFSISM
     LVEGYPAVAN PEGVEVFEIL DEMFFQQFTN VFGESKHFNK ENVSWALQLV NDESLDFSGF
     TFIIAHN
//
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