ID O77368_PLAF7 Unreviewed; 1864 AA.
AC O77368;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 158.
DE SubName: Full=P-type ATPase, putative {ECO:0000313|EMBL:CAB11124.1};
DE EC=3.6.3.1 {ECO:0000313|EMBL:CAB11124.1};
GN ORFNames=PF3D7_0319000 {ECO:0000313|EMBL:CAB11124.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAB11124.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CAB11124.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K., Murphy L., Oliver K.,
RA Quail M.A., Rajandream M.-A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0000313|EMBL:CAB11124.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AL844502; CAB11124.1; -; Genomic_DNA.
DR PIR; T18485; T18485.
DR RefSeq; XP_001351260.1; XM_001351224.1.
DR AlphaFoldDB; O77368; -.
DR STRING; 36329.O77368; -.
DR TCDB; 3.A.3.8.28; the p-type atpase (p-atpase) superfamily.
DR PaxDb; 5833-PFC0840w; -.
DR EnsemblProtists; CAB11124; CAB11124; PF3D7_0319000.
DR GeneID; 814504; -.
DR KEGG; pfa:PF3D7_0319000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0319000; -.
DR HOGENOM; CLU_000846_5_2_1; -.
DR InParanoid; O77368; -.
DR OMA; TWFVISH; -.
DR OrthoDB; 227740at2759; -.
DR PhylomeDB; O77368; -.
DR Reactome; R-PFA-6798695; Neutrophil degranulation.
DR Reactome; R-PFA-936837; Ion transport by P-type ATPases.
DR Proteomes; UP000001450; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015662; F:P-type ion transporter activity; ISS:GeneDB.
DR GO; GO:0006812; P:monoatomic cation transport; ISS:GeneDB.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 2.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF150; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 2.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CAB11124.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1496..1521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1533..1550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1638..1659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1679..1700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1707..1727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1755..1776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..106
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 1466..1601
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
FT DOMAIN 1626..1782
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
FT REGION 301..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1864 AA; 218020 MW; 6A425F4410B1E667 CRC64;
MKILEWISCT IKGKHNENKI YLISNFEFNK DDHEYYIKNA ENRIKEEDLN IDIIYGKKHK
NEIRTAKYKL YSFLPLIVFF QFLRLGNLYF LSISMLQLIP EITDSKGMPT YLIPLVFIIV
VAMIKEFFED WQRHKSDNEE NSKKTMVFVQ GELKEKKWAD VKDGDVVKIF SYEYFPADLI
VLNCSNKKGI VNIETKNVDG ESNVKQKYCL PDISKYFSDD KTAGFCRIEL ISERPNDNIF
DYKGYMILPP LQYKNMKNGK LIHFYNTHYK MDDHKDEHDE KGTGKYINKN YKNDYNDKHI
SYNTNEQNNL SDMTKNDPKE YDYNPQNEIN NNNNNNNCDN NNNNCNNNNR FFVDDIKKQG
QNEETVDKKK SFFIINNQKK VYDTGSSNND QITHINNDVI SEKKRASRRR TLYNKLTFNK
SFFNNKNENK KLNKRNSTLS SINNNNDNNN NNNNNNNNIH NREYDGEEQT LKKENFFFKE
YKRDQKFVQI TIDNLVLRGT SLVNTKWIYG LVINTGNRTK LMKNASTKSR QKWSRLEFVY
GNHVIVLIIC QVFISLIVAI AGVLWMRRKG YTLWYLNLDQ TSDSLKTFFI TIGSMVLLFG
SFIPVDLLLI WEVVRLLQGY LINWDNDMYS EKTGRHALSK AGQLLEEMGN VTHIYSDKTG
TLTQNVMQLQ NIGLGNKGTY GFYDFSNIKE NITKSRHWGS QDPMDPVLEE YENEENVYSN
VNDDNKNDHG TNESDDNNNN NNNNDDDDHH DNNHNIHNDQ NNNAQYDNYD NYYLNNHQQQ
NKVKNRPCID DETNFYRNNN MNKERTRKSY TFLNPLNWSN TSINTKMKKK KSLFYNKNSL
ANYESLLNNT YTEDDFIRGE NEFVFFNRIL FVNKIYSIRH DVQDQIYFLL LVLSLCHSAM
IRNVDIDEMD NNEDDNNNNE KLKIYDKETD IVYTYITQTQ PQYDASSPDE LALISTSLYL
GCEFVNRPNL TTIEIELTST FAQRFILGEK KFEKFLEKKE FYEKEFDTYF PDISACLGKE
KKKDNNKINE MINNKGNTKD DYMNNFHMSI PIKNIFGSNK MQYKEEIKYE EKIIKKVVPI
LSFEILDVFA FDNVRKRMSL IVKNEKKEIF MLVKGADTSV LKLASKNQEN IVDHVEHQLH
AFATSGLRTL VLGYKYLTEN EFSDMYRNHI NARKKSETDK EEYLQEFYEE AENNLIIIGC
TGIDDKLQDD VPQVIQDLRD AGMTICVLTG DKLETAINIG HSINILNKQT YNAIFTETDP
TLLLEQLNIH EKNTNAANLL NVDHGTKWWN SVNWEHLNLD LRSETILNFM KSNFHGSLKK
SIISSNMFNM KNNNSFPSLA RQDKVFNSFL ESSESFCHNN NEMDKTKGKE KVHYSQFSIT
ITGEALDVIM KDKILKIKFY TLARSASTLI ACRVTPKQKS LLVKENSAFN PRGTSLAIGD
GANDVGMILM ANVGVGIAGK EGLQAARSSD FTISEFKYLK KLLFVHGRES LRRNSFLVYF
CIFRNVSFCL CSMILIFWTG YSAIDAWNPW TKQIINIAFT SLPVIFFVAL DKQLPHNILL
NNPLLYETSP STLWPFYSNR KMEFYTNKVK GCYKSFYKFC FFPIRYIPYI QRYTEKIKSW
IGKRSKPEKY RTYGTHYLFV YLLFAIWLAT VETVIMLHFS TGQAYSSSLK DNHHVDIDFN
TFSQILYTHH VIAVNIVVVL MTNTWFFISH VVLWIELIAT FFFWFIISNT KFFLDIIGAD
ELHGTFEKAH SSGNYYASLI ISLYISILPL IILMTYQFIK KPTMEQIVLE QLKLGKFEGL
RKHEIKKLAY IDNQKSSNEF THKGFAFAVE AKEAFWGLVQ KAIYKIKMPL VKDETANIKH
KRKS
//
