ID O83906_TREPA Unreviewed; 357 AA.
AC O83906;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Hemolysin, putative {ECO:0000313|EMBL:AAC65893.1};
GN OrderedLocusNames=TP_0936 {ECO:0000313|EMBL:AAC65893.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65893.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65893.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65893.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
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DR EMBL; AE000520; AAC65893.1; -; Genomic_DNA.
DR PIR; D71262; D71262.
DR RefSeq; WP_010882379.1; NC_021490.2.
DR AlphaFoldDB; O83906; -.
DR SMR; O83906; -.
DR IntAct; O83906; 1.
DR STRING; 243276.TP_0936; -.
DR EnsemblBacteria; AAC65893; AAC65893; TP_0936.
DR KEGG; tpa:TP_0936; -.
DR PATRIC; fig|243276.9.peg.918; -.
DR eggNOG; COG1253; Bacteria.
DR HOGENOM; CLU_776004_0_0_12; -.
DR OrthoDB; 9798188at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF33; UPF0053 PROTEIN YEGH; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 172..228
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 314..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 40514 MW; 9DA9664197261692 CRC64;
MEKCESQPYE IFITIGFVGQ RMKWDWAANI FSLLMGKSWQ RQRARASMLQ MSYADCAVCF
DQGIGSYMVH RTDIVWVEAR ALPSHIFSMI SQHDDYNYFP VCARTIDAVV GYFSVQRYVR
VCLEMERSAG ASREQDEQES VASALHVHME GRRHAHAKGQ GVWIADPVIA RIVQQPIFVP
EVISVRKLLH LFQQMQAQMA FVIDEYGGIE GMVTRDELIM RCVQEYARAD GINSEDCFQN
PDGSWIVSGW MNLNEMYRLG VLARTTRPHT GVHTIAGYVL SIRNRIPRVK EQLNANGCRF
TILKMDGRRI DRLLVEREHP VPSTSGEVPS KGGGKETGDP LSSPRFAKNR KNGPGLK
//
