ID UVRC_MYCAP Reviewed; 571 AA.
AC O84899; A5IYU1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=MAG5020;
OS Mycoplasmopsis agalactiae (strain NCTC 10123 / CIP 59.7 / PG2) (Mycoplasma
OS agalactiae).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae;
OC Mycoplasmopsis.
OX NCBI_TaxID=347257;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9664578; DOI=10.1006/mcpr.1998.0160;
RA Subramaniam S., Bergonier D., Poumarat F., Capaul S., Schlatter Y.,
RA Nicolet J., Frey J.;
RT "Species identification of Mycoplasma bovis and Mycoplasma agalactiae based
RT on the uvrC genes by PCR.";
RL Mol. Cell. Probes 12:161-169(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 10123 / CIP 59.7 / PG2;
RX PubMed=17511520; DOI=10.1371/journal.pgen.0030075;
RA Sirand-Pugnet P., Lartigue C., Marenda M., Jacob D., Barre A., Barbe V.,
RA Schenowitz C., Mangenot S., Couloux A., Segurens B., de Daruvar A.,
RA Blanchard A., Citti C.;
RT "Being pathogenic, plastic, and sexual while living with a nearly minimal
RT bacterial genome.";
RL PLoS Genet. 3:744-758(2007).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; AF003960; AAC32310.1; -; Genomic_DNA.
DR EMBL; CU179680; CAL59200.1; -; Genomic_DNA.
DR RefSeq; WP_011949668.1; NC_009497.1.
DR AlphaFoldDB; O84899; -.
DR SMR; O84899; -.
DR STRING; 347257.MAG5020; -.
DR KEGG; maa:MAG5020; -.
DR HOGENOM; CLU_014841_3_2_14; -.
DR Proteomes; UP000007065; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..571
FT /note="UvrABC system protein C"
FT /id="PRO_0000138315"
FT DOMAIN 15..93
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 184..219
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 571 AA; 66215 MW; 74403690A5FE203C CRC64;
MDKNEIILKL KNTSTSPGVY LWKDAKQNVL YVGKAKNLRK RLLQYFDGAI NSYKTSKLMS
LVADFEVYIC KTNKEALLLE KAMVDRFNPE FNILLLDDRK YPYLKVQLLK DSLLITLSRK
VNTKYTKNTL YYGPFPSGYG AKPILKLLQH EALYESGLLI KNNDSSFWVN QFAKIKEILS
FKNNNYLNEL TNKMHTAANN MQFELALFLR DGLTYLKKLK ESQIIELSQY KNIDVFAYKT
DEKLIYATVL FYRYGVLINK VNLTIPLGIS IDESIRVFFE QFYADKILPD NFIVQEEILK
YDLNLSSDYK FISPKIGTNK KVLDLALLNL NDYYEKEHLI MQNQLEKADS MLSSLNKYLN
LPKLKNIVIF DNSNINNINP VGVAIVYTNG IKNKSLYRKF NLEALSYRSA DVDYIRQSIT
KFFSSDKNTK DFDLIITDGG LQQVNEAKKT LKVLGINIPV IGLVKNEYHK TRALIDLNLN
EIYVNDLELH NYLAQIQIEV DRFAKSHFRN RQKISSLEGK LRNIKGLGHN MEQKLLNHFK
SYAKIYDASV EELAKIVPFN VAKSIKNKDY E
//
