ID O86696_STRCO Unreviewed; 132 AA.
AC O86696;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=6-carboxy-5,6,7,8-tetrahydropterin synthase {ECO:0000256|ARBA:ARBA00018141};
DE EC=4.1.2.50 {ECO:0000256|ARBA:ARBA00012982};
DE AltName: Full=Queuosine biosynthesis protein QueD {ECO:0000256|ARBA:ARBA00031449};
GN OrderedLocusNames=SCO6650 {ECO:0000313|EMBL:CAA20561.1};
GN ORFNames=SC4G2.24 {ECO:0000313|EMBL:CAA20561.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAA20561.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAA20561.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
RN [2] {ECO:0007829|PDB:3D7J}
RP X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 2-132.
RX PubMed=18931427; DOI=10.1107/S1744309108027048;
RA Spoonamore J.E., Roberts S.A., Heroux A., Bandarian V.;
RT "Structure of a 6-pyruvoyltetrahydropterin synthase homolog from
RT Streptomyces coelicolor.";
RL Acta Crystallogr. F Struct. Biol. Commun. 64:875-879(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,8-dihydroneopterin 3'-triphosphate + H2O = 6-
CC carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) +
CC triphosphate; Xref=Rhea:RHEA:27966, ChEBI:CHEBI:15343,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:58462, ChEBI:CHEBI:61032; EC=4.1.2.50;
CC Evidence={ECO:0000256|ARBA:ARBA00001293};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005061}.
CC -!- SIMILARITY: Belongs to the PTPS family. QueD subfamily.
CC {ECO:0000256|ARBA:ARBA00008900}.
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DR EMBL; AL939128; CAA20561.1; -; Genomic_DNA.
DR PIR; T35059; T35059.
DR RefSeq; NP_630726.1; NC_003888.3.
DR RefSeq; WP_011031076.1; NZ_VNID01000002.1.
DR PDB; 3D7J; X-ray; 1.45 A; A/B/C/D/E/F=2-132.
DR PDBsum; 3D7J; -.
DR AlphaFoldDB; O86696; -.
DR SMR; O86696; -.
DR STRING; 100226.gene:17764308; -.
DR PaxDb; 100226-SCO6650; -.
DR PATRIC; fig|100226.15.peg.6755; -.
DR eggNOG; COG0720; Bacteria.
DR HOGENOM; CLU_111016_6_3_11; -.
DR InParanoid; O86696; -.
DR OrthoDB; 9787853at2; -.
DR PhylomeDB; O86696; -.
DR UniPathway; UPA00391; -.
DR EvolutionaryTrace; O86696; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0070497; F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 1.
DR InterPro; IPR007115; 6-PTP_synth/QueD.
DR InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR PANTHER; PTHR12589:SF7; 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR PANTHER; PTHR12589; PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR Pfam; PF01242; PTPS; 1.
DR SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3D7J}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ SEQUENCE 132 AA; 14401 MW; 06886D0BB55EFAF9 CRC64;
MFSITVRDHI MIAHSFRGDV FGPAQRLHGA TFLVDATFRR EQLDEDNIVV DIGLATQELG
AVVGALNYRN LDNEPDFAGV NTSTEFLAKV IADRLAERVH KGALGEGARG LAGLTVTLHE
SHVAWASYER AL
//
