ID SHD_MOUSE Reviewed; 343 AA.
AC O88834; Q3SYI7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 24-JAN-2024, entry version 137.
DE RecName: Full=SH2 domain-containing adapter protein D;
GN Name=Shd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND
RP PHOSPHORYLATION BY ABL.
RC TISSUE=Embryo;
RX PubMed=9315092; DOI=10.1038/sj.onc.1201299;
RA Oda T., Kujovich J., Reis M., Newman B., Druker B.J.;
RT "Identification and characterization of two novel SH2 domain-containing
RT proteins from a yeast two hybrid screen with the ABL tyrosine kinase.";
RL Oncogene 15:1255-1262(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Jaw, and Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as an adapter protein.
CC {ECO:0000269|PubMed:9315092}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O88834-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O88834-2; Sequence=VSP_019860;
CC -!- TISSUE SPECIFICITY: Specifically expressed in brain.
CC {ECO:0000269|PubMed:9315092}.
CC -!- PTM: Tyrosine phosphorylated by ABL. {ECO:0000269|PubMed:9315092}.
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DR EMBL; AB018423; BAA33805.1; -; mRNA.
DR EMBL; AK142491; BAE25084.1; -; mRNA.
DR EMBL; AK164639; BAE37855.1; -; mRNA.
DR EMBL; BC103798; AAI03799.1; -; mRNA.
DR CCDS; CCDS50149.1; -. [O88834-2]
DR CCDS; CCDS89120.1; -. [O88834-1]
DR RefSeq; NP_001152995.1; NM_001159523.1. [O88834-2]
DR RefSeq; NP_033194.1; NM_009168.2. [O88834-1]
DR RefSeq; XP_011244636.1; XM_011246334.2. [O88834-2]
DR AlphaFoldDB; O88834; -.
DR SMR; O88834; -.
DR STRING; 10090.ENSMUSP00000153605; -.
DR iPTMnet; O88834; -.
DR PhosphoSitePlus; O88834; -.
DR PaxDb; 10090-ENSMUSP00000047656; -.
DR PeptideAtlas; O88834; -.
DR ProteomicsDB; 256999; -. [O88834-1]
DR ProteomicsDB; 257000; -. [O88834-2]
DR Antibodypedia; 2789; 102 antibodies from 22 providers.
DR DNASU; 20420; -.
DR Ensembl; ENSMUST00000044216.8; ENSMUSP00000047656.8; ENSMUSG00000039154.9. [O88834-1]
DR Ensembl; ENSMUST00000223629.2; ENSMUSP00000153605.2; ENSMUSG00000039154.9. [O88834-2]
DR GeneID; 20420; -.
DR KEGG; mmu:20420; -.
DR UCSC; uc008dal.2; mouse. [O88834-1]
DR UCSC; uc008dam.2; mouse. [O88834-2]
DR AGR; MGI:1099461; -.
DR CTD; 56961; -.
DR MGI; MGI:1099461; Shd.
DR VEuPathDB; HostDB:ENSMUSG00000039154; -.
DR eggNOG; ENOG502QTRD; Eukaryota.
DR GeneTree; ENSGT00940000159004; -.
DR HOGENOM; CLU_029444_0_1_1; -.
DR InParanoid; O88834; -.
DR OMA; CRAVQLY; -.
DR OrthoDB; 2963819at2759; -.
DR PhylomeDB; O88834; -.
DR TreeFam; TF325799; -.
DR BioGRID-ORCS; 20420; 1 hit in 79 CRISPR screens.
DR ChiTaRS; Shd; mouse.
DR PRO; PR:O88834; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; O88834; Protein.
DR Bgee; ENSMUSG00000039154; Expressed in embryonic brain and 145 other cell types or tissues.
DR ExpressionAtlas; O88834; baseline and differential.
DR Genevisible; O88834; MM.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR CDD; cd10390; SH2_SHD; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035046; SHD_SH2.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF33; SH2 DOMAIN-CONTAINING ADAPTER PROTEIN D; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; SH2 domain.
FT CHAIN 1..343
FT /note="SH2 domain-containing adapter protein D"
FT /id="PRO_0000246774"
FT DOMAIN 225..320
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 1..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 93
FT /note="E -> EQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019860"
SQ SEQUENCE 343 AA; 38481 MW; C55412EEA5AC40EC CRC64;
MAKWLRDYLN LGSRRPPPQP PTPDYTESDI LRAYREQKDL DFEDPYEDSN GRAEPEVTGS
GDPKYNSPRH RLIKVEAADM ARAKALLGSP GEEPEAETEY SDPFDAQPQP PAPNSGYMEP
YDARSVSSEQ PSRAVQLYDT PYEEQATKPE DGGSSGQSRR PLEDERPADE YDQPWEWKKD
HISRAFAVQF DGPDWERTPC STKEPWRPQP AERVDTALAL EKQPWFHGPL SRAEAENLLS
LCKEGSYLVR LSETRAQDCI LSLRSNQGSM HLKFARTREN QVVLGQHSGP FPSIPELVLH
YSARPLPVQG AEHLALLYPV TSSQSSQGPC TLAAKPERGQ GDP
//
