GenomeNet

Database: UniProt
Entry: O94574
LinkDB: O94574
Original site: O94574 
ID   YGDH_SCHPO              Reviewed;         340 AA.
AC   O94574; Q9HFE2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 3.
DT   16-JAN-2019, entry version 114.
DE   RecName: Full=Putative 2-hydroxyacid dehydrogenase C1773.17c;
DE            EC=1.-.-.-;
GN   ORFNames=SPBC1773.17c, SPBP26C9.01c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; CU329671; CAA21922.2; -; Genomic_DNA.
DR   PIR; T39682; T39682.
DR   RefSeq; NP_595132.2; NM_001021039.3.
DR   ProteinModelPortal; O94574; -.
DR   SMR; O94574; -.
DR   BioGrid; 276695; 22.
DR   STRING; 4896.SPBC1773.17c.1; -.
DR   MaxQB; O94574; -.
DR   PaxDb; O94574; -.
DR   PRIDE; O94574; -.
DR   EnsemblFungi; SPBC1773.17c.1; SPBC1773.17c.1:pep; SPBC1773.17c.
DR   GeneID; 2540160; -.
DR   KEGG; spo:SPBC1773.17c; -.
DR   EuPathDB; FungiDB:SPBC1773.17c; -.
DR   PomBase; SPBC1773.17c; -.
DR   HOGENOM; HOG000136700; -.
DR   InParanoid; O94574; -.
DR   OMA; YGAGVDH; -.
DR   PhylomeDB; O94574; -.
DR   Reactome; R-SPO-389661; Glyoxylate metabolism and glycine degradation.
DR   PRO; PR:O94574; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; ISO:PomBase.
DR   GO; GO:0030267; F:glyoxylate reductase (NADP) activity; IBA:GO_Central.
DR   GO; GO:0047964; F:glyoxylate reductase activity; ISO:PomBase.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; IC:PomBase.
DR   GO; GO:0009436; P:glyoxylate catabolic process; ISO:PomBase.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    340       Putative 2-hydroxyacid dehydrogenase
FT                                C1773.17c.
FT                                /FTId=PRO_0000076039.
FT   NP_BIND     169    170       NAD. {ECO:0000250}.
FT   NP_BIND     249    251       NAD. {ECO:0000250}.
FT   NP_BIND     298    301       NAD. {ECO:0000250}.
FT   ACT_SITE    251    251       {ECO:0000250}.
FT   ACT_SITE    280    280       {ECO:0000250}.
FT   ACT_SITE    298    298       Proton donor. {ECO:0000250}.
FT   BINDING     275    275       NAD. {ECO:0000250}.
SQ   SEQUENCE   340 AA;  37658 MW;  44ED8DD371062043 CRC64;
     MKQSRTKRVL AIGELKFATN TLKRLSEKYH FEFIVPDPHD RSKTIEKIHE AASKSTFDAC
     FWLFRNAAIS PFTEEMLGPL LPTCKLFVTG AAGYNNVDVD WATRNGVYVA NTPNGPTEGT
     ANMNLMLFMC TLRGAREAEQ SLRLGKWRQN LSLTDDPYGK RVGIIGMGAI GKSFAQKILP
     LGCEIVYHNR NRLEAEEEKR LGASFVSFDE LLSSSDVISI NCPLTPATHD LISTKEFEKM
     KDGVYIINTA RGAIINEDAF IKAIKSGKVA RAGLDVFLNE PTPNKFWLEC DKVTIQPHCG
     VYTNFTVAKT EECVLASIET FLDTGIPTNP VNGPFGMNGC
//
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