ID O96193_PLAF7 Unreviewed; 235 AA.
AC O96193;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE SubName: Full=Ras-related protein Rab-5A {ECO:0000313|EMBL:CZT98125.1};
DE EC=3.6.5.2 {ECO:0000313|EMBL:CZT98125.1};
GN ORFNames=PF3D7_0211200 {ECO:0000313|EMBL:CZT98125.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98125.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZT98125.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=9804551; DOI=10.1126/science.282.5391.1126;
RA Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L.,
RA Koonin E.V., Shallom S., Mason T., Yu K., Fujii C., Pederson J., Shen K.,
RA Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S., Zhou L.,
RA Sutton G.G., Clayton R., White O., Smith H.O., Fraser C.M., Adams M.D.,
RA Venter J.C., Hoffman S.L.;
RT "Chromosome 2 sequence of the human malaria parasite Plasmodium
RT falciparum.";
RL Science 282:1126-1132(1998).
RN [2] {ECO:0000313|EMBL:CZT98125.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0007829|PDB:3CLV}
RP X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 1-207 IN COMPLEX WITH GDP.
RA Chattopadhyay D., Wernimont A.K., Langsley G., Lew J., Kozieradzki I.,
RA Cossar D., Schapira M., Bochkarev A., Arrowsmith C.H., Bountra C.,
RA Weigelt J., Edwards A.M., Hui R., Sukumar D.;
RT "Crystal Structure of Rab5a from plasmodium falciparum, PFB0500c.";
RL Submitted (MAR-2008) to the PDB data bank.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN999943; CZT98125.1; -; Genomic_DNA.
DR RefSeq; XP_001349618.1; XM_001349582.1.
DR PDB; 3CLV; X-ray; 1.89 A; A=1-207.
DR PDBsum; 3CLV; -.
DR AlphaFoldDB; O96193; -.
DR SMR; O96193; -.
DR STRING; 36329.O96193; -.
DR PaxDb; 5833-PFB0500c; -.
DR EnsemblProtists; CZT98125; CZT98125; PF3D7_0211200.
DR GeneID; 812700; -.
DR KEGG; pfa:PF3D7_0211200; -.
DR VEuPathDB; PlasmoDB:PF3D7_0211200; -.
DR HOGENOM; CLU_041217_10_2_1; -.
DR InParanoid; O96193; -.
DR OMA; DTFHDNT; -.
DR OrthoDB; 5483572at2759; -.
DR PhylomeDB; O96193; -.
DR Reactome; R-PFA-8873719; RAB geranylgeranylation.
DR EvolutionaryTrace; O96193; -.
DR Proteomes; UP000001450; Chromosome 2.
DR GO; GO:0030139; C:endocytic vesicle; IBA:GO_Central.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IDA:GeneDB.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0032889; P:regulation of vacuole fusion, non-autophagic; IDA:GeneDB.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; ISS:GeneDB.
DR CDD; cd01860; Rab5_related; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24073; DRAB5-RELATED; 1.
DR PANTHER; PTHR24073:SF858; RAS-RELATED PROTEIN RAB-24; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3CLV};
KW Hydrolase {ECO:0000313|EMBL:CZT98125.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT BINDING 16
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 18
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 19
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 20
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 21
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 32
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 33
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 35
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 154
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 155
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 157
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 184
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
FT BINDING 185
FT /ligand="GDP"
FT /ligand_id="ChEBI:CHEBI:58189"
FT /evidence="ECO:0007829|PDB:3CLV"
SQ SEQUENCE 235 AA; 26671 MW; 448A6813CDB99A84 CRC64;
MEKKSSYKTV LLGESSVGKS SIVLRLTKDT FHENTNTTIG ASFCTYVVNL NDINIKNNSN
NEKNNNINSI NDDNNVIITN QHNNYNENLC NIKFDIWDTA GQERYASIVP LYYRGATCAI
VVFDISNSNT LDRAKTWVNQ LKISSNYIII LVANKIDKNK FQVDILEVQK YAQDNNLLFI
QTSAKTGTNI KNIFYMLAEE IYKNIINNNN TSKNKTVNKN LINLDNQTLS KKGCC
//
