ID ONCM_BOVIN Reviewed; 245 AA.
AC P53346;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Oncostatin-M;
DE Short=OSM;
DE Flags: Precursor;
GN Name=OSM;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7739518; DOI=10.1128/mcb.15.5.2349;
RA Malik N., Haugen H.S., Modrell B., Shoyab M., Clegg C.H.;
RT "Developmental abnormalities in mice transgenic for bovine oncostatin M.";
RL Mol. Cell. Biol. 15:2349-2358(1995).
CC -!- FUNCTION: Growth regulator. Inhibits the proliferation of a number of
CC tumor cell lines. It regulates cytokine production, including IL-6, G-
CC CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor
CC (heterodimers composed of LIFR and IL6ST) and type II OSM receptor
CC (heterodimers composed of OSMR and IL6ST) (By similarity). Involved in
CC the maturation of fetal hepatocytes, thereby promoting liver
CC development and regeneration (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: Propeptide processing is not important for receptor binding
CC activity but may be important growth-inhibitory activity.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LIF/OSM family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; S78435; AAB34208.1; -; Genomic_DNA.
DR EMBL; S78434; AAB34208.1; JOINED; Genomic_DNA.
DR EMBL; S78487; AAB34208.1; JOINED; Genomic_DNA.
DR PIR; A57417; A57417.
DR AlphaFoldDB; P53346; -.
DR SMR; P53346; -.
DR STRING; 9913.ENSBTAP00000021515; -.
DR GlyCosmos; P53346; 1 site, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000021515; -.
DR eggNOG; ENOG502RVJA; Eukaryota.
DR InParanoid; P53346; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005147; F:oncostatin-M receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0038165; P:oncostatin-M-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0031328; P:positive regulation of cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0010646; P:regulation of cell communication; IEA:UniProt.
DR GO; GO:0023051; P:regulation of signaling; IEA:UniProt.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR InterPro; IPR039578; OSM.
DR PANTHER; PTHR14261; ONCOSTATIN M; 1.
DR PANTHER; PTHR14261:SF0; ONCOSTATIN-M; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00590; LIF_OSM; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW Growth regulation; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..206
FT /note="Oncostatin-M"
FT /evidence="ECO:0000250|UniProtKB:P13725"
FT /id="PRO_0000017719"
FT PROPEP 207..245
FT /evidence="ECO:0000250|UniProtKB:P13725"
FT /id="PRO_0000408763"
FT REGION 143..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..135
FT /evidence="ECO:0000250"
FT DISULFID 71..177
FT /evidence="ECO:0000250"
SQ SEQUENCE 245 AA; 27554 MW; 3372D6E660776C0E CRC64;
MGAQRMQRTL LSLVLRLLLL CTVATGKCSG KYHELLLQLQ RQADLMQDPS TLLDPYIHLQ
GLHSPVLQEH CRERPGDFPS EDALWRLSRQ DFLQTLNTTL GLILRMLSAL QQDLPEAAHQ
QAEMNVRGFG NNIHCMAQLL RGSSDPKAAE PTQPGPGPTP LPPTPPSSTF QRKLRNCGFL
RGYHRFMRTA GQVLRGWGER QGRSRRHSPC RALKRGARRT QPFPEIRRLA PRGQPPGSLW
GAPAR
//
