ID OR4K5_HUMAN Reviewed; 323 AA.
AC Q8NGD3; Q6IFA7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 153.
DE RecName: Full=Olfactory receptor 4K5;
DE AltName: Full=Olfactory receptor OR14-16;
GN Name=OR4K5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K5";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065882; BAC06100.1; -; Genomic_DNA.
DR EMBL; BK004355; DAA04753.1; -; Genomic_DNA.
DR CCDS; CCDS32024.1; -.
DR RefSeq; NP_001005483.1; NM_001005483.1.
DR AlphaFoldDB; Q8NGD3; -.
DR SMR; Q8NGD3; -.
DR STRING; 9606.ENSP00000319511; -.
DR GlyCosmos; Q8NGD3; 1 site, No reported glycans.
DR GlyGen; Q8NGD3; 1 site.
DR BioMuta; OR4K5; -.
DR DMDM; 38372673; -.
DR MassIVE; Q8NGD3; -.
DR PaxDb; 9606-ENSP00000319511; -.
DR PeptideAtlas; Q8NGD3; -.
DR Antibodypedia; 58520; 62 antibodies from 16 providers.
DR DNASU; 79317; -.
DR Ensembl; ENST00000315915.5; ENSP00000319511.3; ENSG00000176281.5.
DR Ensembl; ENST00000708873.1; ENSP00000517391.1; ENSG00000291822.1.
DR GeneID; 79317; -.
DR KEGG; hsa:79317; -.
DR MANE-Select; ENST00000315915.5; ENSP00000319511.3; NM_001005483.1; NP_001005483.1.
DR UCSC; uc010tkw.3; human.
DR AGR; HGNC:14745; -.
DR CTD; 79317; -.
DR GeneCards; OR4K5; -.
DR HGNC; HGNC:14745; OR4K5.
DR HPA; ENSG00000176281; Not detected.
DR neXtProt; NX_Q8NGD3; -.
DR OpenTargets; ENSG00000176281; -.
DR PharmGKB; PA32320; -.
DR VEuPathDB; HostDB:ENSG00000176281; -.
DR eggNOG; ENOG502T9M0; Eukaryota.
DR GeneTree; ENSGT00940000163286; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGD3; -.
DR OMA; IVTHYLR; -.
DR OrthoDB; 5116051at2759; -.
DR PhylomeDB; Q8NGD3; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGD3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79317; 5 hits in 736 CRISPR screens.
DR GeneWiki; OR4K5; -.
DR GenomeRNAi; 79317; -.
DR Pharos; Q8NGD3; Tdark.
DR PRO; PR:Q8NGD3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGD3; Protein.
DR ExpressionAtlas; Q8NGD3; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR CDD; cd15226; 7tmA_OR4-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48002:SF56; OLFACTORY RECEPTOR 4K5; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 4K5"
FT /id="PRO_0000150555"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 319
FT /note="R -> K (in dbSNP:rs17242341)"
FT /id="VAR_034200"
SQ SEQUENCE 323 AA; 36258 MW; D4EE96021A34F29A CRC64;
MDKSNSSVVS EFVLLGLCSS QKLQLFYFCF FSVLYTVIVL GNLLIILTVT SDTSLHSPMY
FLLGNLSFVD ICQASFATPK MIADFLSAHE TISFSGCIAQ IFFIHLFTGG EMVLLVSMAY
DRYVAICKPL YYVVIMSRRT CTVLVMISWA VSLVHTLSQL SFTVNLPFCG PNVVDSFFCD
LPRVTKLACL DSYIIEILIV VNSGILSLST FSLLVSSYII ILVTVWLKSS AAMAKAFSTL
ASHIAVVILF FGPCIFIYVW PFTISPLDKF LAIFYTVFTP VLNPIIYTLR NRDMKAAVRK
IVNHYLRPRR ISEMSLVVRT SFH
//
