ID OR6C2_HUMAN Reviewed; 312 AA.
AC Q9NZP2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 27-MAR-2024, entry version 153.
DE RecName: Full=Olfactory receptor 6C2;
DE AltName: Full=HSA3;
GN Name=OR6C2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-283, AND VARIANT PRO-209.
RX PubMed=10706615; DOI=10.1073/pnas.040580197;
RA Rouquier S., Blancher A., Giorgi D.;
RT "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT reduction of the functional fraction in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6C2";
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DR EMBL; AC122685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF179766; AAF40351.1; -; Genomic_DNA.
DR CCDS; CCDS31824.1; -.
DR RefSeq; NP_473446.1; NM_054105.1.
DR AlphaFoldDB; Q9NZP2; -.
DR SMR; Q9NZP2; -.
DR STRING; 9606.ENSP00000493222; -.
DR GlyCosmos; Q9NZP2; 2 sites, No reported glycans.
DR GlyGen; Q9NZP2; 2 sites.
DR iPTMnet; Q9NZP2; -.
DR PhosphoSitePlus; Q9NZP2; -.
DR BioMuta; OR6C2; -.
DR DMDM; 85541047; -.
DR PaxDb; 9606-ENSP00000323606; -.
DR PeptideAtlas; Q9NZP2; -.
DR Antibodypedia; 58545; 43 antibodies from 14 providers.
DR DNASU; 341416; -.
DR Ensembl; ENST00000641202.1; ENSP00000493222.1; ENSG00000179695.3.
DR Ensembl; ENST00000641516.1; ENSP00000493456.1; ENSG00000179695.3.
DR GeneID; 341416; -.
DR KEGG; hsa:341416; -.
DR MANE-Select; ENST00000641202.1; ENSP00000493222.1; NM_054105.2; NP_473446.1.
DR UCSC; uc001sgz.1; human.
DR AGR; HGNC:15436; -.
DR CTD; 341416; -.
DR GeneCards; OR6C2; -.
DR HGNC; HGNC:15436; OR6C2.
DR HPA; ENSG00000179695; Not detected.
DR neXtProt; NX_Q9NZP2; -.
DR OpenTargets; ENSG00000179695; -.
DR PharmGKB; PA32580; -.
DR VEuPathDB; HostDB:ENSG00000179695; -.
DR eggNOG; ENOG502T9K4; Eukaryota.
DR GeneTree; ENSGT01090000260006; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q9NZP2; -.
DR OMA; WYIVRTI; -.
DR OrthoDB; 5401587at2759; -.
DR PhylomeDB; Q9NZP2; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q9NZP2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9NZP2; -.
DR BioGRID-ORCS; 341416; 11 hits in 738 CRISPR screens.
DR GeneWiki; OR6C2; -.
DR GenomeRNAi; 341416; -.
DR Pharos; Q9NZP2; Tdark.
DR PRO; PR:Q9NZP2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NZP2; Protein.
DR ExpressionAtlas; Q9NZP2; baseline and differential.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR CDD; cd15912; 7tmA_OR6C-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR047132; Olfact_rcpt_6C-like.
DR PANTHER; PTHR26454; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26454:SF8; OLFACTORY RECEPTOR 6C2; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 6C2"
FT /id="PRO_0000150624"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 181
FT /note="P -> A (in dbSNP:rs11171466)"
FT /id="VAR_034243"
FT VARIANT 209
FT /note="L -> P (in dbSNP:rs11171467)"
FT /evidence="ECO:0000269|PubMed:10706615"
FT /id="VAR_034244"
SQ SEQUENCE 312 AA; 35178 MW; 8362872FB2D1CE23 CRC64;
MKNHTVIRTF ILLGLTGDPH LQVLLFIFLF LTYMLSVTGN LTIITLTLVD HHLKTPMYFF
LRNFSFLEVS FTTVCIPRFL YNISMGDNTI TYNACASQIF FVILFGATEF FLLAAMSYDR
YVAICKPLHY VVIMNNRVCT LLVLCCWVAG LMIIVPPLSL GLQLEFCDSN AIDHFSCDAG
PLLKISCSDT WVIEQMVILM AVFALIITLV CVILSYLYIV RTILKFPSVQ QRKKAFSTCS
SHMIVVSIAY GSCIFIYIKP SAKDEVAINK GVSVLTTSVA PLLNPFIYTL RNKQVKQAFS
DSIKRIAFLS KK
//
