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Entry: P00218
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ID   FER_THEAC               Reviewed;         143 AA.
AC   P00218; Q9V304;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   16-JAN-2019, entry version 119.
DE   RecName: Full=Zinc-containing ferredoxin;
GN   Name=zfx; OrderedLocusNames=Ta1448;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 /
OS   NBRC 15155 / AMRC-C165).
OC   Archaea; Euryarchaeota; Diaforarchaea group; Thermoplasmata;
OC   Thermoplasmatales; Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=HO-62;
RX   PubMed=10438486; DOI=10.1074/jbc.274.33.23160;
RA   Cosper N.J., Stalhandske C.M.V., Iwasaki H., Oshima T., Scott R.A.,
RA   Iwasaki T.;
RT   "Structural conservation of the isolated zinc site in archaeal zinc-
RT   containing ferredoxins as revealed by X-ray absorption spectroscopic
RT   analysis and its evolutionary implications.";
RL   J. Biol. Chem. 274:23160-23168(1999).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-143.
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RA   Wakabayashi S., Fujimoto N., Wada K., Matsubara H., Kerscher L.,
RA   Oesterhelt D.;
RT   "Amino acid sequence of a ferredoxin from thermoacidophilic
RT   archaebacteria, Thermoplasma acidophilum.";
RL   FEBS Lett. 162:21-24(1983).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-16, AND CHARACTERIZATION.
RC   STRAIN=HO-62;
RX   PubMed=9013590; DOI=10.1074/jbc.272.6.3453;
RA   Iwasaki T., Suzuki T., Kon T., Imai T., Urushiyama A., Ohmori D.,
RA   Oshima T.;
RT   "Novel zinc-containing ferredoxin family in thermoacidophilic
RT   archaea.";
RL   J. Biol. Chem. 272:3453-3458(1997).
CC   -!- FUNCTION: Ferredoxins are iron-sulfur proteins that transfer
CC       electrons in a wide variety of metabolic reactions.
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC       Note=Binds 1 [3Fe-4S] cluster.;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion.;
CC   -!- MASS SPECTROMETRY: Mass=15961; Mass_error=10; Method=MALDI;
CC       Range=2-143; Evidence={ECO:0000269|PubMed:10438486};
DR   EMBL; AL445067; CAC12568.1; -; Genomic_DNA.
DR   EMBL; AB023294; BAA82797.1; -; Genomic_DNA.
DR   PIR; T37333; FEYTA.
DR   ProteinModelPortal; P00218; -.
DR   SMR; P00218; -.
DR   STRING; 273075.Ta1448m; -.
DR   EnsemblBacteria; CAC12568; CAC12568; CAC12568.
DR   KEGG; tac:Ta1448; -.
DR   eggNOG; arCOG04548; Archaea.
DR   eggNOG; COG1146; LUCA.
DR   OMA; CMACESV; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR009157; Fd_Zn-bd.
DR   Pfam; PF00037; Fer4; 2.
DR   PIRSF; PIRSF000068; Zn_Fdx_Sulfol; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   1: Evidence at protein level;
KW   3Fe-4S; 4Fe-4S; Complete proteome; Direct protein sequencing;
KW   Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Reference proteome; Repeat; Transport; Zinc.
FT   INIT_MET      1      1       Removed. {ECO:0000269|PubMed:9013590,
FT                                ECO:0000269|Ref.3}.
FT   CHAIN         2    143       Zinc-containing ferredoxin.
FT                                /FTId=PRO_0000159182.
FT   DOMAIN       60     89       4Fe-4S ferredoxin-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN      115    143       4Fe-4S ferredoxin-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   REGION       13     60       N-terminal extension.
FT   METAL        31     31       Zinc. {ECO:0000305}.
FT   METAL        34     34       Zinc. {ECO:0000305}.
FT   METAL        58     58       Zinc. {ECO:0000305}.
FT   METAL        69     69       Iron-sulfur 1 (3Fe-4S). {ECO:0000305}.
FT   METAL        75     75       Iron-sulfur 1 (3Fe-4S). {ECO:0000305}.
FT   METAL        79     79       Iron-sulfur 2 (4Fe-4S). {ECO:0000305}.
FT   METAL       117    117       Zinc. {ECO:0000305}.
FT   METAL       124    124       Iron-sulfur 2 (4Fe-4S). {ECO:0000305}.
FT   METAL       127    127       Iron-sulfur 2 (4Fe-4S). {ECO:0000305}.
FT   METAL       130    130       Iron-sulfur 2 (4Fe-4S). {ECO:0000305}.
FT   METAL       134    134       Iron-sulfur 1 (3Fe-4S). {ECO:0000305}.
FT   VARIANT     102    102       Q -> E (in strain: HO-62).
FT   VARIANT     106    106       E -> A (in strain: HO-62).
SQ   SEQUENCE   143 AA;  16093 MW;  5DA840A7856B165D CRC64;
     MVKLEELDFK PKPIDEHFLE NDKDYPVTGQ HNGHDVRAEG MQRLDADGKP YPTKLGIHGT
     HVAVDWDCCI ADGACMDVCP VNLYEWNLNP GKSGTGNDHK IQKGSEEWNK YRTDKCDPVR
     ESDCIFCMAC ESVCPVRAIK ITP
//
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