ID LAC3_MOUSE Reviewed; 104 AA.
AC P01845;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=Ig lambda-3 chain C region;
GN Name=Iglc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6812053; DOI=10.1073/pnas.79.15.4681;
RA Selsing E., Miller J., Wilson R., Storb U.;
RT "Evolution of mouse immunoglobulin lambda genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:4681-4685(1982).
RN [2]
RP PROTEIN SEQUENCE OF 1-18 (MYELOMA PROTEIN CBPC-49).
RA Breyer R.M., Sauer R.T., Eisen H.N.;
RT "The variable region of mouse lambda-3 chains.";
RL ICN UCLA Symp. Mol. Cell. Biol. 20:105-110(1981).
RN [3]
RP PROTEIN SEQUENCE OF 10-104 (MYELOMA PROTEIN CBPC-49 AND MONOCLONAL ANTIBODY
RP 8-47).
RX PubMed=6165998; DOI=10.1073/pnas.78.1.569;
RA Azuma T., Steiner L.A., Eisen H.N.;
RT "Identification of a third type of lambda light chain in mouse
RT immunoglobulins.";
RL Proc. Natl. Acad. Sci. U.S.A. 78:569-573(1981).
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DR EMBL; J00585; AAB59670.1; -; Genomic_DNA.
DR PIR; B93922; L3MS.
DR PIR; S22762; S22762.
DR AlphaFoldDB; P01845; -.
DR SMR; P01845; -.
DR MaxQB; P01845; -.
DR PeptideAtlas; P01845; -.
DR ProteomicsDB; 263693; -.
DR AGR; MGI:99886; -.
DR MGI; MGI:99886; Iglc3.
DR InParanoid; P01845; -.
DR OMA; IDSAHEC; -.
DR PhylomeDB; P01845; -.
DR Reactome; R-MMU-166663; Initial triggering of complement.
DR Reactome; R-MMU-173623; Classical antibody-mediated complement activation.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-MMU-2029481; FCGR activation.
DR Reactome; R-MMU-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-MMU-2029485; Role of phospholipids in phagocytosis.
DR Reactome; R-MMU-2168880; Scavenging of heme from plasma.
DR Reactome; R-MMU-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-MMU-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-MMU-2871796; FCERI mediated MAPK activation.
DR Reactome; R-MMU-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-MMU-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-MMU-5690714; CD22 mediated BCR regulation.
DR Reactome; R-MMU-977606; Regulation of Complement cascade.
DR Reactome; R-MMU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR ChiTaRS; Iglc3; mouse.
DR PRO; PR:P01845; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01845; Protein.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0071735; C:IgG immunoglobulin complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
DR CDD; cd07699; IgC1_L; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF98; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Immunoglobulin domain;
KW Reference proteome.
FT CHAIN <1..104
FT /note="Ig lambda-3 chain C region"
FT /id="PRO_0000153610"
FT DOMAIN 6..99
FT /note="Ig-like"
FT DISULFID 27..85
FT DISULFID 103
FT /note="Interchain (with heavy chain)"
FT NON_TER 1
SQ SEQUENCE 104 AA; 11371 MW; 83CEBCD4AA348EF1 CRC64;
QPKSTPTLTM FPPSPEELQE NKATLVCLIS NFSPSGVTVA WKANGTPITQ GVDTSNPTKE
DNKYMASSFL HLTSDQWRSH NSFTCQVTHE GDTVEKSLSP AECL
//
