ID IGHD_MOUSE Reviewed; 257 AA.
AC P01881;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 13-SEP-2023, entry version 138.
DE RecName: Full=Ig delta chain C region secreted form;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-248 (TEPC 1017).
RX PubMed=6968091; DOI=10.1126/science.6968091;
RA Tucker P.W., Liu C.-P., Mushinski J.F., Blattner F.R.;
RT "Mouse immunoglobulin D: messenger RNA and genomic DNA sequences.";
RL Science 209:1353-1360(1980).
RN [2]
RP PROTEIN SEQUENCE OF 231-257 (B1-8.DELTA-1).
RX PubMed=6895102; DOI=10.1038/292061a0;
RA Dildrop R., Beyreuther K.;
RT "C-terminal sequence of the secreted form of mouse IgD heavy chain.";
RL Nature 292:61-63(1981).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-257.
RX PubMed=6801528; DOI=10.1038/296410a0;
RA Cheng H.-L., Blattner F.R., Fitzmaurice L., Mushinski J.F., Tucker P.W.;
RT "Structure of genes for membrane and secreted murine IgD heavy chains.";
RL Nature 296:410-415(1982).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Secreted;
CC IsoId=P01881-1; Sequence=Displayed;
CC Name=Membrane-bound;
CC IsoId=P01882-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Cell lines producing IgD contain several mRNA
CC species for Ig delta chains. In plasmacytomas, the secreted form is the
CC major component, and the membrane-bound form is a minor component. In
CC spleen, however, the membrane-bound form is the major component. These
CC two forms differ in their C-terminal segments.
CC -!- MISCELLANEOUS: This delta chain lacks the domain corresponding to the
CC CH2 domain of human delta chain.
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DR EMBL; J00447; AAB59652.1; -; Genomic_DNA.
DR EMBL; J00448; AAB59652.1; JOINED; Genomic_DNA.
DR EMBL; J00449; AAB59652.1; JOINED; Genomic_DNA.
DR EMBL; J00450; AAB59652.1; JOINED; Genomic_DNA.
DR PIR; A02176; DHMS.
DR AlphaFoldDB; P01881; -.
DR SMR; P01881; -.
DR GlyGen; P01881; 5 sites.
DR InParanoid; P01881; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01881; Protein.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR23411:SF25; IG DELTA CHAIN C REGION MEMBRANE-BOUND FORM-RELATED; 1.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Immunoglobulin domain; Reference proteome; Repeat; Secreted.
FT CHAIN <1..257
FT /note="Ig delta chain C region secreted form"
FT /id="PRO_0000153571"
FT DOMAIN 5..105
FT /note="Ig-like 1"
FT DOMAIN 133..233
FT /note="Ig-like 2"
FT REGION 89..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 13
FT /note="Interchain (with light chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 26..78
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 155
FT /note="Interchain (with heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 1
SQ SEQUENCE 257 AA; 28368 MW; 7277EED06840C44E CRC64;
DKKEPDMFLL SECKAPEENE KINLGCLVIG SQPLKISWEP KKSSIVEHVF PSEMRNGNYT
MVLQVTVLAS ELNLNHTCTI NKPKRKEKPF KFPESWDSQS SKRVTPTLQA KNHSTEATKA
ITTKKDIEGA MAPSNLTVNI LTTSTHPEMS SWLLCEVSGF FPENIHLMWL GVHSKMKSTN
FVTANPTAQP GGTFQTWSVL RLPVALSSSL DTYTCVVEHE ASKTKLNASK SLAISGCYHL
LPESDGPSRR PDGPALA
//
