ID HSP23_DROME Reviewed; 186 AA.
AC P02516; Q9VSX5;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 27-MAR-2024, entry version 180.
DE RecName: Full=Heat shock protein 23;
GN Name=Hsp23; ORFNames=CG4463;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6302284; DOI=10.1016/s0022-2836(83)80241-1;
RA Southgate R., Ayme A., Voellmy R.;
RT "Nucleotide sequence analysis of the Drosophila small heat shock gene
RT cluster at locus 67B.";
RL J. Mol. Biol. 165:35-57(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6285380; DOI=10.1073/pnas.79.7.2360;
RA Ingolia T.D., Craig E.A.;
RT "Four small Drosophila heat shock proteins are related to each other and to
RT mammalian alpha-crystallin.";
RL Proc. Natl. Acad. Sci. U.S.A. 79:2360-2364(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; J01100; AAA28637.1; -; Genomic_DNA.
DR EMBL; V00210; CAA23494.1; -; Genomic_DNA.
DR EMBL; X03889; CAA27525.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50286.1; -; Genomic_DNA.
DR EMBL; AY061081; AAL28629.1; -; mRNA.
DR PIR; A02919; HHFF23.
DR PIR; B20647; B20647.
DR RefSeq; NP_001246694.1; NM_001259765.2.
DR RefSeq; NP_523999.1; NM_079275.4.
DR AlphaFoldDB; P02516; -.
DR SMR; P02516; -.
DR BioGRID; 64472; 66.
DR DIP; DIP-18765N; -.
DR IntAct; P02516; 7.
DR STRING; 7227.FBpp0301282; -.
DR PaxDb; 7227-FBpp0301282; -.
DR DNASU; 39077; -.
DR EnsemblMetazoa; FBtr0076453; FBpp0076181; FBgn0001224.
DR EnsemblMetazoa; FBtr0309504; FBpp0301282; FBgn0001224.
DR GeneID; 39077; -.
DR KEGG; dme:Dmel_CG4463; -.
DR AGR; FB:FBgn0001224; -.
DR CTD; 39077; -.
DR FlyBase; FBgn0001224; Hsp23.
DR VEuPathDB; VectorBase:FBgn0001224; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00940000166889; -.
DR HOGENOM; CLU_095001_3_0_1; -.
DR InParanoid; P02516; -.
DR OMA; YYCQRRR; -.
DR OrthoDB; 2953415at2759; -.
DR PhylomeDB; P02516; -.
DR Reactome; R-DME-3371571; HSF1-dependent transactivation.
DR SignaLink; P02516; -.
DR BioGRID-ORCS; 39077; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Hsp23; fly.
DR GenomeRNAi; 39077; -.
DR PRO; PR:P02516; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0001224; Expressed in embryonic/larval hemocyte (Drosophila) and 41 other cell types or tissues.
DR ExpressionAtlas; P02516; baseline and differential.
DR Genevisible; P02516; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IDA:FlyBase.
DR GO; GO:0061077; P:chaperone-mediated protein folding; IDA:FlyBase.
DR GO; GO:0009631; P:cold acclimation; IEP:FlyBase.
DR GO; GO:0042026; P:protein refolding; IDA:FlyBase.
DR GO; GO:0009408; P:response to heat; IDA:FlyBase.
DR GO; GO:0001666; P:response to hypoxia; IMP:FlyBase.
DR CDD; cd06526; metazoan_ACD; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640:SF13; HEAT SHOCK PROTEIN 22-RELATED; 1.
DR PANTHER; PTHR45640; HEAT SHOCK PROTEIN HSP-12.2-RELATED; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..186
FT /note="Heat shock protein 23"
FT /id="PRO_0000125964"
FT DOMAIN 53..161
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 163..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 31..33
FT /note="QRN -> RRI (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="K -> E (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="K -> G (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="L -> V (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="N -> S (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="N -> G (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 20629 MW; 3C6EDCDA1719B5A0 CRC64;
MANIPLLLSL ADDLGRMSMV PFYEPYYCQR QRNPYLALVG PMEQQLRQLE KQVGASSGSS
GAVSKIGKDG FQVCMDVSHF KPSELVVKVQ DNSVLVEGNH EEREDDHGFI TRHFVRRYAL
PPGYEADKVA STLSSDGVLT IKVPKPPAIE DKGNERIVQI QQVGPAHLNV KENPKEAVEQ
DNGNDK
//
