ID KIT_FSVHZ Reviewed; 370 AA.
AC P04048;
DT 01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1986, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Tyrosine-protein kinase transforming protein kit;
DE EC=2.7.10.1;
GN Name=V-KIT;
OS Feline sarcoma virus (strain Hardy-Zuckerman 4).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus;
OC Hardy-Zuckerman feline sarcoma virus.
OX NCBI_TaxID=11777;
OH NCBI_TaxID=9681; Felidae (cat family).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3007997; DOI=10.1038/320415a0;
RA Besmer P., Murphy J.E., George P.C., Qiu F., Bergold P.J., Lederman L.,
RA Snyder H.W. Jr., Brodeur D., Zuckerman E.E., Hardy W.D.;
RT "A new acute transforming feline retrovirus and relationship of its
RT oncogene v-kit with the protein kinase gene family.";
RL Nature 320:415-421(1986).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC -!- DOMAIN: Lacks the transmembrane and extracellular domains.
CC -!- MISCELLANEOUS: This protein is synthesized as a Gag-Kit-Pol
CC polyprotein.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00159}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X03711; CAA27339.1; -; Genomic_DNA.
DR SMR; P04048; -.
DR BRENDA; 2.7.10.1; 2234.
DR Proteomes; UP000242259; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR PANTHER; PTHR24416:SF46; MAST_STEM CELL GROWTH FACTOR RECEPTOR KIT; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein;
KW Transferase; Tyrosine-protein kinase.
FT CHAIN 1..370
FT /note="Tyrosine-protein kinase transforming protein kit"
FT /id="PRO_0000155208"
FT DOMAIN 27..370
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ACT_SITE 230
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 33..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 61
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 261
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000250"
SQ SEQUENCE 370 AA; 41849 MW; 71D32BEDEFE25F2D CRC64;
EEINGNNYID PTQLPYDHKW EFPRNRLSFG KTLGAGAFGK VVEATAYGLI KSDAAMTVAV
KMLKPSAHLT EREALMSELK VLSYLGNHMN IVNLLGACTV GGPTLVITEY CCYGDLLNFL
RRKRDSFICS KQEDHAEVAL YKNLLQSKES SCNDSTNEYM DMKPGVSYVV PTKADKRRSA
RIGSYIERDV TPAIMEDGEL ALDLEDLLSF SYQVAKGMAF LASKNCIHRD LAARNILLTH
GRITKICDFG LARDIKNDSN YVVKGNARLP VKWMAPESIF NCVYTFESDV WSYGIFLWEL
FSLGSSPYPG MPVDSKFYKM IKEGFRMLSP EHAPAEMYDI MKTCWDADPL KRPTFKQIVQ
LIEKQKNKNE
//
