ID   UBX_DROFU               Reviewed;         253 AA.
AC   P05048;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Homeotic protein ultrabithorax;
DE   Flags: Fragment;
GN   Name=Ubx;
OS   Drosophila funebris (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16453766; DOI=10.1002/j.1460-2075.1987.tb02380.x;
RA   Wilde C.D., Akam M.;
RT   "Conserved sequence elements in the 5' region of the Ultrabithorax
RT   transcription unit.";
RL   EMBO J. 6:1393-1401(1987).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds the
CC       consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls
CC       development of the cells in the posterior thoracic and first abdominal
CC       segments. It activates the synthesis of the decapentaplegic (DPP)
CC       growth factor (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X05177; CAA28811.1; -; Genomic_DNA.
DR   EMBL; X05177; CAA28812.1; ALT_TERM; Genomic_DNA.
DR   PIR; A33144; A33144.
DR   AlphaFoldDB; P05048; -.
DR   FlyBase; FBgn0012305; Dfun\Ubx.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; TAS:UniProtKB.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..>253
FT                   /note="Homeotic protein ultrabithorax"
FT                   /id="PRO_0000200266"
FT   REGION          125..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           237..242
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        125..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         253
SQ   SEQUENCE   253 AA;  24555 MW;  D9A5672AA0851031 CRC64;
     MNSYFEQASG FYGHPHQASG MAMGSGGHHD QTTASAAAAA YRGFTLPLGM SPYANHHLQR
     TTQDSPYDAS ITAACNKIYG DAGSAYKQDC LNIKADAVNG YKDIWNTGGA NGGGGGGGGG
     AATAGNTSNG SNAPNAANGQ NNAGGGGMPV RPSACTPDSR VGGYLDTSGG SPVSHRGGGS
     AGGGNGTAGG VPQNSASGVG GGVGAGTAWN ANCTISGAAA AQTAAASSLH QPGNHTFYPW
     MAIAGESTAD PIK
//