ID MLE_TODPA Reviewed; 160 AA.
AC P05945;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Myosin catalytic light chain LC-1, mantle muscle;
OS Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Decapodiformes; Oegopsida; Ommastrephidae; Todarodes.
OX NCBI_TaxID=6637;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=3790251; DOI=10.1515/bchm3.1986.367.2.1025;
RA Watanabe B., Maita T., Konno K., Matsuda G.;
RT "Amino-acid sequence of LC-1 light chain of squid mantle muscle myosin.";
RL Biol. Chem. Hoppe-Seyler 367:1025-1032(1986).
CC -!- FUNCTION: In molluscan muscle, calcium regulation is associated with
CC myosin rather than with actin. Muscle myosin contains two types of
CC light chains: the catalytic light chain, essential for ATPase activity,
CC and the regulatory light chain, a calcium-binding protein responsible
CC for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
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DR PIR; A25571; A25571.
DR PDB; 3I5F; X-ray; 3.10 A; C=2-160.
DR PDB; 3I5G; X-ray; 2.60 A; C=2-160.
DR PDB; 3I5H; X-ray; 3.40 A; C=2-160.
DR PDB; 3I5I; X-ray; 3.30 A; C=2-160.
DR PDBsum; 3I5F; -.
DR PDBsum; 3I5G; -.
DR PDBsum; 3I5H; -.
DR PDBsum; 3I5I; -.
DR SMR; P05945; -.
DR EvolutionaryTrace; P05945; -.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23048; MYOSIN LIGHT CHAIN 1, 3; 1.
DR PANTHER; PTHR23048:SF33; MYOSIN, ESSENTIAL LIGHT CHAIN; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR SMART; SM00054; EFh; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Motor protein; Muscle protein;
KW Myosin; Repeat.
FT CHAIN 1..160
FT /note="Myosin catalytic light chain LC-1, mantle muscle"
FT /id="PRO_0000198724"
FT DOMAIN 7..44
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 83..118
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 119..153
FT /note="EF-hand 3"
FT /evidence="ECO:0000305"
FT MOD_RES 1
FT /note="Blocked amino end (Xaa)"
FT HELIX 6..22
FT /evidence="ECO:0007829|PDB:3I5G"
FT STRAND 25..27
FT /evidence="ECO:0007829|PDB:3I5G"
FT HELIX 31..33
FT /evidence="ECO:0007829|PDB:3I5G"
FT HELIX 34..40
FT /evidence="ECO:0007829|PDB:3I5G"
FT HELIX 47..51
FT /evidence="ECO:0007829|PDB:3I5G"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:3I5G"
FT STRAND 57..61
FT /evidence="ECO:0007829|PDB:3I5I"
FT HELIX 66..76
FT /evidence="ECO:0007829|PDB:3I5G"
FT HELIX 85..95
FT /evidence="ECO:0007829|PDB:3I5G"
FT STRAND 99..103
FT /evidence="ECO:0007829|PDB:3I5G"
FT HELIX 105..114
FT /evidence="ECO:0007829|PDB:3I5G"
FT STRAND 115..117
FT /evidence="ECO:0007829|PDB:3I5G"
FT HELIX 121..130
FT /evidence="ECO:0007829|PDB:3I5G"
FT STRAND 139..142
FT /evidence="ECO:0007829|PDB:3I5I"
FT HELIX 143..152
FT /evidence="ECO:0007829|PDB:3I5G"
SQ SEQUENCE 160 AA; 18171 MW; 37F32498B4EA3BE2 CRC64;
XSQLTKDEIE EVREVFDLFD FWDGRDGDVD AAKVGDLLRC LGMNPTEAQV HQHGGTKKMG
EKAYKLEEIL PIYEEMSSKD TGTAADEFME AFKTFDREGQ GLISSAEIRN VLKMLGERIT
EDQCNDIFTF CDIREDIDGN IKYEDLMKKV MAGPFPDKSD
//
