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Database: UniProt
Entry: P07605
LinkDB: P07605
Original site: P07605 
ID   KITH_RFVKA              Reviewed;         178 AA.
AC   P07605; Q9Q910;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   16-JAN-2019, entry version 70.
DE   RecName: Full=Thymidine kinase;
DE            EC=2.7.1.21;
GN   Name=TK; ORFNames=s061R;
OS   Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain
OS   Kasza)).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Leporipoxvirus.
OX   NCBI_TaxID=10272;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3023681;
RA   Upton C., McFadden G.;
RT   "Identification and nucleotide sequence of the thymidine kinase gene
RT   of Shope fibroma virus.";
RL   J. Virol. 60:920-927(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3014722; DOI=10.1016/0042-6822(86)90134-0;
RA   Upton C., McFadden G.;
RT   "Tumorigenic poxviruses: analysis of viral DNA sequences implicated in
RT   the tumorigenicity of Shope fibroma virus and malignant rabbit
RT   virus.";
RL   Virology 152:308-321(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1660196; DOI=10.1016/0042-6822(91)90529-K;
RA   Strayer D.S., Jerng H.H., O'Connor K.;
RT   "Sequence and analysis of a portion of the genomes of Shope fibroma
RT   virus and malignant rabbit fibroma virus that is important for viral
RT   replication in lymphocytes.";
RL   Virology 185:585-595(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562495; DOI=10.1006/viro.1999.0002;
RA   Willer D.O., McFadden G., Evans D.H.;
RT   "The complete genome sequence of shope (Rabbit) fibroma virus.";
RL   Virology 264:319-343(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21;
CC   -!- SIMILARITY: Belongs to the thymidine kinase family. {ECO:0000305}.
DR   EMBL; M14493; AAA47227.1; -; Genomic_DNA.
DR   EMBL; AF170722; AAF17943.1; -; Genomic_DNA.
DR   PIR; A26102; KIVZSF.
DR   RefSeq; NP_051950.1; NC_001266.1.
DR   ProteinModelPortal; P07605; -.
DR   SMR; P07605; -.
DR   GeneID; 1486904; -.
DR   KEGG; vg:1486904; -.
DR   Proteomes; UP000000868; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA synthesis; Kinase; Metal-binding;
KW   Nucleotide-binding; Reference proteome; Transferase; Zinc.
FT   CHAIN         1    178       Thymidine kinase.
FT                                /FTId=PRO_0000174935.
FT   NP_BIND      13     20       ATP. {ECO:0000250}.
FT   REGION      159    163       Substrate binding. {ECO:0000250}.
FT   ACT_SITE     85     85       Proton acceptor. {ECO:0000255}.
FT   METAL       140    140       Zinc. {ECO:0000250}.
FT   METAL       143    143       Zinc. {ECO:0000250}.
FT   METAL       172    172       Zinc. {ECO:0000250}.
FT   METAL       175    175       Zinc. {ECO:0000250}.
FT   BINDING     115    115       Substrate; via amide nitrogen.
FT                                {ECO:0000250}.
FT   CONFLICT      2      3       Missing (in Ref. 1; AAA47227).
FT                                {ECO:0000305}.
FT   CONFLICT    102    102       A -> R (in Ref. 1; AAA47227).
FT                                {ECO:0000305}.
SQ   SEQUENCE   178 AA;  19896 MW;  51A7775471A99D53 CRC64;
     MTMYGGHIHL IIGPMFAGKS TELIRLVRRY QIAKHKCLVV KYEKDIRYGN GVCTHDNMSI
     TAVCTPSLDK IDSVAENAEV IGIDEGQFFP NIATFCERMA NAGKVLIVAA LDGTFQRKPF
     SNISELIPLA ENVTKLNAVC MYCYKNGSFS KRLGDKMEIE VIGGSDKYKS VCRKCYFF
//
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