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Database: UniProt
Entry: P0C1E9
LinkDB: P0C1E9
Original site: P0C1E9 
ID   YPRB2_CORML             Reviewed;         304 AA.
AC   P0C1E9; P45637;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=Uncharacterized protein in proB 3'region;
DE            EC=1.-.-.-;
OS   Corynebacterium melassecola.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=41643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 17965 / AS B-4821;
RX   PubMed=8755867; DOI=10.1128/jb.178.15.4412-4419.1996;
RA   Ankri S., Serebrijski I., Reyes O., Leblon G.;
RT   "Mutations in the Corynebacterium glutamicum proline biosynthetic
RT   pathway: a natural bypass of the proA step.";
RL   J. Bacteriol. 178:4412-4419(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 229-304.
RC   STRAIN=ATCC 17965 / AS B-4821;
RX   PubMed=8522535; DOI=10.1128/jb.177.24.7255-7260.1995;
RA   Serebrijski I., Wojcik F., Reyes O., Leblon G.;
RT   "Multicopy suppression by asd gene and osmotic stress-dependent
RT   complementation by heterologous proA in proA mutants.";
RL   J. Bacteriol. 177:7255-7260(1995).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; U31230; AAC44175.1; -; Genomic_DNA.
DR   EMBL; X82929; CAA58102.1; -; Genomic_DNA.
DR   PIR; S49979; S49979.
DR   PIR; T50667; T50667.
DR   ProteinModelPortal; P0C1E9; -.
DR   SMR; P0C1E9; -.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    304       Uncharacterized protein in proB 3'region.
FT                                /FTId=PRO_0000236033.
FT   NP_BIND     136    137       NAD. {ECO:0000250}.
FT   NP_BIND     215    217       NAD. {ECO:0000250}.
FT   NP_BIND     265    268       NAD. {ECO:0000250}.
FT   ACT_SITE    217    217       {ECO:0000250}.
FT   ACT_SITE    246    246       {ECO:0000250}.
FT   ACT_SITE    265    265       Proton donor. {ECO:0000250}.
FT   BINDING     241    241       NAD. {ECO:0000250}.
SQ   SEQUENCE   304 AA;  33037 MW;  601C37DD5BCAD6E7 CRC64;
     MKFVMYPHLW ESTTAVIEGG GHERVEDIKD ADFIFFNGSA PEFPDLPENI KFVQASMAGI
     DALVKRGVVN EKARWANAAG LYADTVAEST IGLILAQMHM HAATRLAKSW SVRPEVENNK
     SWLHDNKTVA ILGAGGIGVR LLEMLKPFNV KTIAVNNSGR PVEGADETFA MDKAEHVWAE
     ADVFVLILPL TDATYQIVNA ETLGKMKPSA VLVNVGRGPL INTDDLVDAL NNGTIAGAAL
     DVTDPEPLPD SHPLWEMDNV VITPHTANTN ERIRALTGEL TLRNIELFEA GEQMATEVDV
     VAGY
//
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