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Database: UniProt
Entry: P0C2N8
LinkDB: P0C2N8
Original site: P0C2N8 
ID   DRS1_NEUCR              Reviewed;         829 AA.
AC   P0C2N8; A7UVU0; Q7RZX6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   16-OCT-2019, entry version 76.
DE   RecName: Full=ATP-dependent RNA helicase drs1;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box RNA helicase 11;
GN   Name=drh-11; Synonyms=drs1; ORFNames=NCU00235, NCU11175;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CM002238; EDO65410.2; -; Genomic_DNA.
DR   RefSeq; XP_001728501.2; XM_001728449.2.
DR   SMR; P0C2N8; -.
DR   PRIDE; P0C2N8; -.
DR   EnsemblFungi; EDO65410; EDO65410; NCU11175.
DR   GeneID; 5847888; -.
DR   KEGG; ncr:NCU11175; -.
DR   EuPathDB; FungiDB:NCU11175; -.
DR   HOGENOM; HOG000265456; -.
DR   InParanoid; P0C2N8; -.
DR   KO; K13181; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN         1    829       ATP-dependent RNA helicase drs1.
FT                                /FTId=PRO_0000282494.
FT   DOMAIN      324    498       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      528    707       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     337    344       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       293    321       Q motif.
FT   MOTIF       446    449       DEAD box.
FT   COMPBIAS     65    267       Asp-rich.
FT   COMPBIAS    736    829       Lys-rich.
SQ   SEQUENCE   829 AA;  92026 MW;  CEBE6005FCB04234 CRC64;
     MAPSQKRKAI DDDFILTISD NEEDIPLEEE QEVVPRKKAK TATQQSNKQK KKNNKKSKKQ
     QQTEDDDDEA ETKEDDAADL GIWGDNDEDD GAMDTEFQFV VDGQNEVDAE FDGWGFEGAH
     KGVVKGANAG GDKKAVDIDE IIRRRRERKA AKEGKTTATK EEEDKMEVDE EEDDIEEIDV
     DLDDDEDGVL ADDAFGMGVG SDVEEEEEKQ DAKMGGVDGE DEDSEGEDGE KKGEDEDEGD
     ASDDDSVATA VEHPDDVQSS DDEEGIDEEE EAKMKEFFAP EEENQPKKKG EMSSFQEMSL
     SRPILRGLTS VGFTKPTPIQ AKTIPISLMG KDVVGGAVTG SGKTAAFVVP ILERLLYRPK
     KVPTTRVVIL TPTRELAIQC HAVAVKLASH TDIKFCLAVG GLSLKVQEAE LRLRPDVVIA
     TPGRFIDHMR NSASFAVDTI EILVLDEADR MLEDGFADEL NEILTTLPKS RQTMLFSATM
     TSSVDRLIRA GLNKPVRIMA DSQKKTAGTL VQEFVRLRPG RESKREGYLL HICKTIYTER
     VIIFFRQKKI AHKMRIIFGL FGLSCAELHG SMNQAQRIQS VEDFRDGKVN FLLATDLASR
     GLDIKGVDTV INYEAPQTPE IYVHRVGRTA RAGRSGTAIT LAAEPDRKVV KAAVKAGKSQ
     GAKISSRIID PADADKWQAE IDELEDEIEE IMQEEKEEKQ LQNMEMQVKK GENMIKYEDE
     ISSRPKRTWF ETQEDKKKAK AAGRAELNGV RDKLKSKNEG KLSNKDRKKL DTMQERKQER
     TYKKGSAERA GKGAVLNLKK VVKKVGRSAG PKKKGGNAGK GGKGKGRRK
//
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