ID DC8L2_HUMAN Reviewed; 631 AA.
AC P0C7V8; B2RXH9; J3KT06;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=DDB1- and CUL4-associated factor 8-like protein 2;
DE AltName: Full=WD repeat-containing protein 42C;
GN Name=DCAF8L2; Synonyms=WDR42C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the WD repeat DCAF8 family. {ECO:0000305}.
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DR EMBL; BC157859; AAI57860.1; -; mRNA.
DR EMBL; AC006210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59162.1; -.
DR RefSeq; NP_001130005.1; NM_001136533.1.
DR AlphaFoldDB; P0C7V8; -.
DR SMR; P0C7V8; -.
DR BioGRID; 131438; 25.
DR IntAct; P0C7V8; 1.
DR STRING; 9606.ENSP00000462745; -.
DR iPTMnet; P0C7V8; -.
DR PhosphoSitePlus; P0C7V8; -.
DR BioMuta; DCAF8L2; -.
DR DMDM; 519668665; -.
DR EPD; P0C7V8; -.
DR jPOST; P0C7V8; -.
DR MassIVE; P0C7V8; -.
DR MaxQB; P0C7V8; -.
DR PaxDb; 9606-ENSP00000462745; -.
DR PeptideAtlas; P0C7V8; -.
DR ProteomicsDB; 52378; -.
DR Pumba; P0C7V8; -.
DR Antibodypedia; 66936; 65 antibodies from 13 providers.
DR Ensembl; ENST00000451261.7; ENSP00000462745.1; ENSG00000189186.11.
DR Ensembl; ENST00000545306.2; ENSP00000479800.1; ENSG00000189186.11.
DR MANE-Select; ENST00000451261.7; ENSP00000462745.1; NM_001353450.2; NP_001340379.1.
DR UCSC; uc011mjy.2; human.
DR AGR; HGNC:31811; -.
DR GeneCards; DCAF8L2; -.
DR HGNC; HGNC:31811; DCAF8L2.
DR HPA; ENSG00000189186; Tissue enriched (testis).
DR neXtProt; NX_P0C7V8; -.
DR OpenTargets; ENSG00000189186; -.
DR VEuPathDB; HostDB:ENSG00000189186; -.
DR eggNOG; KOG1334; Eukaryota.
DR GeneTree; ENSGT00950000182900; -.
DR HOGENOM; CLU_012381_4_1_1; -.
DR InParanoid; P0C7V8; -.
DR OMA; FASGHKN; -.
DR OrthoDB; 66220at2759; -.
DR PhylomeDB; P0C7V8; -.
DR TreeFam; TF326071; -.
DR PathwayCommons; P0C7V8; -.
DR SignaLink; P0C7V8; -.
DR BioGRID-ORCS; 347442; 13 hits in 809 CRISPR screens.
DR ChiTaRS; DCAF8L2; human.
DR GenomeRNAi; 347442; -.
DR Pharos; P0C7V8; Tdark.
DR PRO; PR:P0C7V8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P0C7V8; Protein.
DR Bgee; ENSG00000189186; Expressed in right testis and 21 other cell types or tissues.
DR ExpressionAtlas; P0C7V8; baseline and differential.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045151; DCAF8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15574:SF42; DDB1- AND CUL4-ASSOCIATED FACTOR 8-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR15574; WD REPEAT DOMAIN-CONTAINING FAMILY; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..631
FT /note="DDB1- and CUL4-associated factor 8-like protein 2"
FT /id="PRO_0000344462"
FT REPEAT 226..265
FT /note="WD 1"
FT REPEAT 269..310
FT /note="WD 2"
FT REPEAT 316..356
FT /note="WD 3"
FT REPEAT 364..404
FT /note="WD 4"
FT REPEAT 420..459
FT /note="WD 5"
FT REPEAT 467..507
FT /note="WD 6"
FT REPEAT 511..550
FT /note="WD 7"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..148
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..617
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 345
FT /note="T -> A (in dbSNP:rs5926895)"
FT /id="VAR_045620"
FT CONFLICT 145..147
FT /note="Missing (in Ref. 1; AAI57860)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 631 AA; 71191 MW; 04C398AEE033EB3A CRC64;
MSHQEGSTDG LPDLGTESLF SSPEEQSGAV AATEASSDID IATSELSVTV TGDGSDSRDG
GFPNDASTEN RSSDQESASE DIELESLEDF EHFLMSGESL FHYPLVGEEE TEREEEDEEI
QEEGGEEEEE EEEEEEEEEE EEEEEEEQPR AGPQGSGGNH EQYSLEEDQA LEEWVSSETS
ALPRPRWQVV TALHQRQLGS RPRFVYEACG ARAFVQRFRL QYRLADHVGC VNTVHFNQRG
TRLASSGDDL KVIVWDWVRQ RPVLNFESGH TNNVFQAKFL PNCGDSTLAM CARDGQVRVA
ELINASYFNN TKCVAQHRGP AHKLALEPDS PYKFLTSGED AVVFTIDLRQ DRPASKVVVT
RENDKKVGLY TITVNPANTY QFAVGGQDQF VRIYDQRKID KKENNGVLKK FTPHHLVNCD
FPTNITCVVY SHDGTELLAS YNDDDIYLFN SSHSDGAQYS KRFKGHRNNT TVKGVNFYGP
RSEFVVSGSD CGHIFFWEKS SCQIIQFLKG SREGTINCLE PHPYLPVLAC SGLDHDVKIW
TPTAKAATEL TGLKKVIKKN KWERDEDSLH HGSLFDQYML WFLLRHVTQR GRHQDWRSGE
AEFPDEESDE SSSTSETSEE EVQDRVQCMP S
//
