ID MS3L2_HUMAN Reviewed; 447 AA.
AC P0C860;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 08-NOV-2023, entry version 75.
DE RecName: Full=Putative male-specific lethal-3 protein-like 2;
DE Short=MSL3-like 2;
DE AltName: Full=Male-specific lethal-3 homolog 2;
DE AltName: Full=Male-specific lethal-3 homolog pseudogene 1;
GN Name=MSL3P1; Synonyms=MSL3L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 40-447.
RC TISSUE=Cervix carcinoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in chromatin remodeling and transcriptional
CC regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00972}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC005538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR623684; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0C860; -.
DR SMR; P0C860; -.
DR IntAct; P0C860; 4.
DR iPTMnet; P0C860; -.
DR PhosphoSitePlus; P0C860; -.
DR BioMuta; HGNC:17837; -.
DR DMDM; 205829193; -.
DR EPD; P0C860; -.
DR jPOST; P0C860; -.
DR MassIVE; P0C860; -.
DR MaxQB; P0C860; -.
DR PeptideAtlas; P0C860; -.
DR ProteomicsDB; 52398; -.
DR Pumba; P0C860; -.
DR AGR; HGNC:17837; -.
DR GeneCards; MSL3P1; -.
DR HGNC; HGNC:17837; MSL3P1.
DR neXtProt; NX_P0C860; -.
DR InParanoid; P0C860; -.
DR PhylomeDB; P0C860; -.
DR PathwayCommons; P0C860; -.
DR Pharos; P0C860; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C860; Protein.
DR GO; GO:0072487; C:MSL complex; IBA:GO_Central.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.274.30; MRG domain; 2.
DR InterPro; IPR008676; MRG.
DR InterPro; IPR038217; MRG_C_sf.
DR InterPro; IPR026541; MRG_dom.
DR PANTHER; PTHR10880:SF37; MALE-SPECIFIC LETHAL-3 PROTEIN-LIKE 2-RELATED; 1.
DR PANTHER; PTHR10880; MORTALITY FACTOR 4-LIKE PROTEIN; 1.
DR Pfam; PF05712; MRG; 1.
DR PROSITE; PS51640; MRG; 1.
PE 5: Uncertain;
KW Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..447
FT /note="Putative male-specific lethal-3 protein-like 2"
FT /id="PRO_0000348253"
FT DOMAIN 32..90
FT /note="Chromo"
FT DOMAIN 93..441
FT /note="MRG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00972"
FT REGION 35..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 51070 MW; 9EBC7C8A9DBE225A CRC64;
MPDRACAVGS VARALSRSRR YVCARDADAS RRRRRPFNYG LSIEEKNEND ENSLSSSSDS
SEDKDEKISE ECDIEEKTEV KEEPELQTKR EMEERTVTLE IPEVLKRQLE DDCYYINRRK
RLVQLPCHTN IITILESYVK HFAISAAFSA NERPRHHHAM PHASMNVPYI PAEKNIDLCK
EMVDGLRITF DYTLPLVLLY PYEQAQYKKV TASKVFLAIK ESATNTNRSQ EKLSPSLRLL
NPSRPQSTES QSTSGEPATP KRRKAEPQAV QSLRRSSPHT ANCDRLSKSS TSPQPKRWQQ
DMSTSVPKLF LHLEKKTPVH SRSSSPTLTP SQEGSPVFAG FEGRRTNEIN EVLSWKLVPD
NYPPGDQPPP PSYIYGAQHL LRLFVKLPEI LGKMSFTEKN LKALLKHFDL FVRFLAEYHD
DFFPESAYVA ASEVHYSTRN PQAVNKC
//
