GenomeNet

Database: UniProt
Entry: P0CG36
LinkDB: P0CG36
Original site: P0CG36 
ID   CFC1B_HUMAN             Reviewed;         223 AA.
AC   P0CG36; B2RCY0; B9EJD3; Q53T05; Q9GZR3;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   RecName: Full=Cryptic family protein 1B;
DE   Flags: Precursor;
GN   Name=CFC1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
CC       {ECO:0000305}.
CC   -!- CAUTION: This gene differs from CFC1 by only one residue at
CC       position 78:R -> W. R78W is also thought to be a CFC1
CC       polymorphism. {ECO:0000305}.
DR   EMBL; AC013269; AAY14955.1; -; Genomic_DNA.
DR   CCDS; CCDS33286.1; -.
DR   RefSeq; NP_001072998.1; NM_001079530.1.
DR   UniGene; Hs.503733; -.
DR   ProteinModelPortal; P0CG36; -.
DR   SMR; P0CG36; -.
DR   STRING; 9606.ENSP00000281882; -.
DR   BioMuta; CFC1B; -.
DR   DMDM; 300680885; -.
DR   PaxDb; P0CG36; -.
DR   PRIDE; P0CG36; -.
DR   ProteomicsDB; 52466; -.
DR   Ensembl; ENST00000281882; ENSP00000281882; ENSG00000152093.
DR   GeneID; 653275; -.
DR   KEGG; hsa:653275; -.
DR   UCSC; uc002trl.3; human.
DR   CTD; 653275; -.
DR   DisGeNET; 653275; -.
DR   EuPathDB; HostDB:ENSG00000152093.7; -.
DR   GeneCards; CFC1B; -.
DR   HGNC; HGNC:33983; CFC1B.
DR   HPA; HPA041773; -.
DR   neXtProt; NX_P0CG36; -.
DR   OpenTargets; ENSG00000152093; -.
DR   PharmGKB; PA162382207; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410XP6K; LUCA.
DR   GeneTree; ENSGT00940000162302; -.
DR   HOGENOM; HOG000090236; -.
DR   InParanoid; P0CG36; -.
DR   OMA; PYSWAFG; -.
DR   OrthoDB; 1387592at2759; -.
DR   PhylomeDB; P0CG36; -.
DR   TreeFam; TF333187; -.
DR   ChiTaRS; CFC1B; human.
DR   GeneWiki; Cripto; -.
DR   GenomeRNAi; 653275; -.
DR   PRO; PR:P0CG36; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000152093; Expressed in 21 organ(s), highest expression level in substantia nigra.
DR   ExpressionAtlas; P0CG36; baseline.
DR   Genevisible; P0CG36; HS.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0070697; F:activin receptor binding; IBA:GO_Central.
DR   GO; GO:0038100; F:nodal binding; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR   GO; GO:0007368; P:determination of left/right symmetry; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IBA:GO_Central.
DR   GO; GO:0038092; P:nodal signaling pathway; IBA:GO_Central.
DR   InterPro; IPR019011; Cryptic/Cripto_CFC-dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   Pfam; PF09443; CFC; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Developmental protein; Disulfide bond;
KW   EGF-like domain; Gastrulation; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26    223       Cryptic family protein 1B.
FT                                /FTId=PRO_0000395408.
FT   DOMAIN       86    115       EGF-like. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   CARBOHYD     52     52       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     90     97       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     91    103       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    105    114       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   223 AA;  24642 MW;  457EB443BC0CF1A5 CRC64;
     MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE
     VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR
     SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCDPK DFLASHAHGP SAGGAPSLLL
     LLPCALLHRL LRPDAPAHPR SLVPSVLQRE RRPCGRPGLG HRL
//
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