GenomeNet

Database: UniProt
Entry: P0CQ74
LinkDB: P0CQ74
Original site: P0CQ74 
ID   DED1_CRYNJ              Reviewed;         637 AA.
AC   P0CQ74; Q55YR5; Q5KN36;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   16-OCT-2019, entry version 46.
DE   RecName: Full=ATP-dependent RNA helicase ded1;
DE            EC=3.6.4.13;
GN   Name=DED1; OrderedLocusNames=CNA07860;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /
OS   ATCC MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in translation
CC       initiation. Remodels RNA in response to ADP and ATP concentrations
CC       by facilitating disruption, but also formation of RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AE017341; AAW41314.1; -; Genomic_DNA.
DR   RefSeq; XP_567133.1; XM_567133.1.
DR   SMR; P0CQ74; -.
DR   STRING; 5207.AAW41314; -.
DR   PaxDb; P0CQ74; -.
DR   PRIDE; P0CQ74; -.
DR   EnsemblFungi; AAW41314; AAW41314; CNA07860.
DR   GeneID; 3253536; -.
DR   KEGG; cne:CNA07860; -.
DR   EuPathDB; FungiDB:CNA07860; -.
DR   eggNOG; KOG0335; Eukaryota.
DR   eggNOG; ENOG410XNTI; LUCA.
DR   InParanoid; P0CQ74; -.
DR   KO; K11594; -.
DR   OMA; CYRSWVR; -.
DR   OrthoDB; 595675at2759; -.
DR   Proteomes; UP000002149; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043186; C:P granule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN         1    637       ATP-dependent RNA helicase ded1.
FT                                /FTId=PRO_0000232157.
FT   DOMAIN      191    384       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      395    556       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     204    211       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       160    188       Q motif.
FT   MOTIF       328    331       DEAD box.
SQ   SEQUENCE   637 AA;  68050 MW;  D3BD775D690B0958 CRC64;
     MAATDVNGLA SQMNSVNLNG ASQKPQKPAY VPPHLRNRAA PPAAVPPAAP AAYRPSPTGL
     PTPATTPPTR HIVPAAVAED DVGGWGAQPR VRKTFEHGAP PGFGSWKNGQ HVVGARNTRM
     EKEMYGEVGD GLHQATGINF DKYADIPVEV SGKGVPEPVT EFTNPPINPV LLENVKYARY
     ATPTPVQKYS IPIVADGRDL MACAQTGSGK TGGFLFPILS ALFTYGPSTP PVEQDTGYGY
     RRTKKVYPTA LVLAPTRELV SQIHEEARKF AYRSWVRPAV VYGGADIGSQ MRALDRGCDL
     LSATPGRLVD LIERGKISLA NVKYLVLDEA DRMLDMGFEP QIRRIVDEED MPGVLERQTL
     MFSATFPREI QNLARSFLKE YIFLTVGRVG STSENITQRV EYVDDQDKRS LLLDLLLAEQ
     SGGLILVFVE TKRMADTLCD FLCSRRHNAT SIHGDRTQRE REAALYAFKS GRAPILVATA
     VAARGLDIPN VTHVILYDLP NDVAEYTHRI GRTGRAGNVG TSTAFFNRGN TNIGKDLIEL
     LKEANQEVPQ WLVEISSERS YGGGGGGGYK GSRGRSTGGG GGARLGGRDM RQGGGGYGGG
     GRTSGYGGGY GGGGGGAGWG SGGGFPPAGG DSGASWW
//
DBGET integrated database retrieval system